Home > Archive>Volume 14, Issue 5, 2014 >842-845. DOI:10.3980/j.issn.1672-5123.2014.05.15
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New trends and clinical significance of very small embryonic-like stem cells in Ophthalmology
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    Abstract:

    Very small embryonic-like stem cells(VSELs)is a rare population of pluripotent adult stem cells, whose biological nature is similar to that of embryonic stem cells, firstly identified in murine bone marrow(BM)and human cord blood(CB)by Kucia and his group in University of Louisville. They have similar outlook to embryonic stem cells such as cell morphology and markers and similar inner pluripotent characteristics which make them be the most potential seed cells in the cell replacement therapy. In this review, we will focus on research advance about VSELs and clinical significance in the stem cell transplantation treatment of retinal degenerative diseases.

    Reference
    1 Colter DC,Sekiya I,Prockop DJ.Identification of a subpopulation of rapidly self renewing and multipotential adult stem cells in colonies of human marrow stromal cells.Proc Natl Acad Sci USA 2001; 98(14):7841-7845
    2 Jiang Y,Jahagirdar BN,Reinhardt RL,et al.Pluripotency of mesenchymal stem cells derived from adult marrow.Nature 2002; 418(6893):41-49
    3 Kucia M, Reca R, Campbell FR, et al. A population of very small emhryonic-like(VSEL)CXCR4(+)SSEA-1(+)Oct-4(+)stem cells identified in adult bone marrow. Leukemia 2006; 20(5):857-869
    4 Kucia M,Wysoczynski M,Ratajczak J,et al.Identification of very small embryonic like(VSEL)stem cells in bone marrow.Cell Tissue Res 2008; 331(1):125-134
    5 Kucia M,Halasa M,Wysoczynski M,et al.Morphological and molecular characterization of novel population of CXCR4+SSEA-4+Oct-4+ very small embryonicdike cells purified from human cord blood:preliminary report.Leukemia 2007; 21(2):297-303
    6 Halasa M,Baskiewicz-Masiuk M,Dabkowska E,et al.An efficient two-step method to purify very small embryonic-like(VSEL)stem cells from umbilical cord blood(UCB).Folia Histoehem Cytobiol 2008; 46(2):239-243
    7 Zuba-Surma EK, Kucia M, Abdel-Latif A, et al.Morphological characterization of very small embryonic-like stem cells(VSELs)by Imagestream syslem analysis.J Cell Mol Med 2008; 12(1):292-303
    8 Liu Y,Gao L,Zuba-Surma EK,et al.Identification of small Sca-l(+),Lin(-),CD45(-)multipotential cells in the neonatal murine retina.Exp Hematol 2009; 37(9):1096-1107
    9 Danova-Alt R, Heider A, Egger D, et al.Very small embryonic-like stem cells purified from umbilical cord blood lack stem cell characteristics. PLoS One 2012; 7(4):e34899
    10 Ratajczak MZ,Zuba-Surma E,Wojakowski W,et al.Very small embryonic-like stem cells(VSELs)represent a real challenge in stem cell biology: recent pros and cons in the midst of a lively debate.Leukemia 2014; 28(3):473-484
    11 Murry CE, Soonpaa MH, Reinecke H, et al. Haematopoietic stem cells do not transdifferentiate into cardiac myocytes in myocardial infarcts. Nature 2004; 428(6983):664-668
    12 Kucia MJ, Wysoczynski M, Wu W, et al. Evidence that very small embryonic-like stem cells are mobilized into peripheral blood. Stem Cells 2008; 26(8):2083-2092
    13 Zuba-Surma EK, Kucia M, Dawn B, et al. Bone marrow-derived pluripotent very small embryonic-like stem cells(VSELs)are mobilized after acute myocacdial infarction. J Mol Cell Cardiol 2008; 44(5):865-873
    14 Kucia M, Zhang YP, Reca R, et al. Cells enriched in markers of neural tissue-committed stem cells reside in the bone marrow and are mobilized into peripheral blood following stroke. Leukemia 2006; 20(1):18-28
    15 Paczkowska E, Kucia M, Koziarska D, et al. Clinical evidence that very small embryonic-like stem cells are mobilized into peripheral blood in patients after stroke. Stroke 2009; 40(4):1237-1244
    16 Wojakowski W, Tenders M, Kucia M, et al. Mobilization of bone marrow-derived Oct-4 + SSEA-4 + very small embryonic-like stem cells in patients with acute myocardial infarction. J Am Coll Cardiol 2009; 53(1): 1-9
    17 Abdel-Latif A, Zuba-Surma EK, Ziada KM, et al. Evidence of mobilization of pluripotent stem cells into peripheral blood of patients with myocardial ischemia. Exp Hematol 2010; 38(12):1131-1142
    18 Ratajczak MZ,Machalinski B,Wojakowski W,et al.A hypothesis for an embryonic origin of pluripotent Oct-4(+ )stem cells in adult bone marrow and other tissues.Leukemia 2007; 21(5):860-867
    19 Mizrak SC, Chikhovskaya JV, Sadri-Ardekani H, et al. Embryonic stem cell-like cells derived from adult human testis. Human Reproduction 2010; 25(1):158-167
    20 Gong SP, Lee ST, Lee EJ, et al.Embryonic stem cell like cells established by culture of adult ovarian cells in mice. Fertil Steril 2010; 93(8):2594-2601
    21 Miyanishi M, Mori Y, Seita J, et al.Do pluripotent stem cells exist in adult mice as very small embryonic stem cells? Stem Cell Reports 2013; 1(2):198-208
    22郭慧娟,王健,张兴秀,等.粒细胞集落刺激因子对骨髓极小胚胎样干细胞的动员和募集.中国组织工程研究与临床康复 2011; 15(14):2530-2534
    23 Ratajczak J, Zuba-Surma E, Paczkowska E, et al. Stem cells for neural regeneration-a potential application of very small embryonic-like stem cells. J Physiol Pharmacol 2011; 62(1):3-12
    24 Tang XL,Rokosh DG,Guo Y,et al.Cardiac progenitor cels and bone marrowderived very small embryonic-like stem cells for cardiac repair after myocardial infarction.Circ J 2010; 74(3):390-404
    25 Dawn B,Tiwari S,Kucia MJ,et al.Transplantation of bone marrow-derived very smart embryonic-like stem cells attenuates left ventricular dysfunction and remodeling after myocardial infarction.Stem Cells 2008; 26(6):1646-1655
    26 Zuba-Surma EK,Wu W,Ratajczak J,et al.Very small embryonic-like stem cells in adult tissues:potential implications for aging.Mech Ageing Dev 2009; 130(1-2):58-66
    27 Zuba-Surma EK, Guo Y, Taher H, et al.Transplantatian of expanded bone marrow-derived very small embryonic-like stem cells(VSEL-SCs)improves left ventricular function and remodeling after myocardial infarction. J Cell Mol Med 2011; 15(6):1319-1328
    28 Machalifiska A,Baumert B,Kuprjanowicz L,et al.Potential application of adult stem cells in retinal repair-challenge for regenerative medicine.Curt Eye Res 2009; 34(9):748-760
    29 Meyer JS,Shearer RL,Capowski EE,et al.Modeling early retinal development with human embryonic and induced pluripotent stem cells.Proe Natl Acad sci USA 2009; 106(39):16698-16703
    30 Lamba DA,Gust J,Reh TA.Transplantation of human embryonic stem cell-derived photoreceptors restores some visual function in crx-deficient mice.Cell Stem Cell 2009; 4(1):73-79
    31 Lu B,Maleuit C,Wang S,et al. Long-term safety and function of RPE from human embryonic stem cells in preclinical models of macular degeneration.Stem Cells 2009; 27(9):2126-2135
    32 Jian Q,Xu H,Xie H,et al.Activation of retinal stem cells in the proliferating marginal region of RCS rats during development of retinitis pigmentosa.Neuresci Lett 2009; 465(1):41-44
    33 Shin DM, Liu R, Wu W,et al. Global gene expression analysis of very small embryonic-like stem cells reveals that the Ezh2-dependent bivalent domain mechanism contributes to their pluripotent state. Stem Cells Dev 2012; 21(10):1639-1652
    34 Kassmer SH, Krause DS. Very small embryonic-like cells: biology and function of these potential endogenous pluripotent stem cells in adult tissues. Mol Reprod Dev 2013; 80(8):677-690
    35 Mierzejewska K, Heo J, Kang JW,et al.Genome-wide analysis of murine bone marrowderived very small embryonic-like stem cells reveals that mitogenic growth factor signaling pathways play a crucial role in the quiescence and ageing of these cells. Int J Mol Med 2013; 32(2):281-290
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Qing Xiao, Ling Gao, Luo- Sheng Tang,/et al.New trends and clinical significance of very small embryonic-like stem cells in Ophthalmology. Guoji Yanke Zazhi( Int Eye Sci) 2014;14(5):842-845

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Publication History
  • Received:January 23,2014
  • Revised:April 10,2014
  • Online: April 21,2014
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