AIM:To improve the efficacy pathological changes of retinal microvessel in the early damp-heat diabetic patients from TCM theory of shuganlizhuo.

METHODS: Totally 56 patients with early damp-heat diabetic, 28 cases in treatment group and another 28 cases in control group. The treatment group treated with shuganlizhuo prescription(Shuhe capsules), the control group with Acarbose, all in a row with three courses. TCM syndrome manifestations, visual acuity, field of vision, as well as 2h postprandial blood glucose(P2HBG)and glycosylated hemoglobin(HbA1c)between the two groups before and after treatment were observed.

RESULTS: The treatment group was able to significantly improve the TCM symptoms(P<0.01), P2HBG, and HbA1c, improved visual acuity(P<0.05), reduced visual field defects MD average values(P<0.01).

CONCLUSION: The method of shuganlizhuo has improved micro lesions of early damp-heat diabetic retinal effects may be related to improve the systemic symptoms.