AIM:To investigate the main reasons,effects and complications of penetrating keratoplasty.

METHOTS: Retrospective analysis on 150 cases(150 eyes)of penetrating keratoplasty was done from Jan.2011 to June 2013.

RESULTS: Reasons: coneal lecuma 99 eyes(66%); corneal degeneration 18 eyes(12%); corneal ulcers 15 eyes(10%); corneal endothelium decompensation 10 eyes(6.7%); keratoconus 8 eyes(5.3%). Effects: Grafts were transparent in 110 eyes(73.3%). There are 42 eyes(28%)less than or equal to 0.05 in visual acuity,60 eyes(40%)better than 0.05 and less than or equal to 0.3 and 48 eyes(32%)better than 0.3. Complication: The main complication was immune rejection(28 eyes, 18.7%).

CONCLUSION: Penetrating keratoplasty is an important and effective means for keratitis disease.