AIM: To explore the curative effect of methylprednisolone with octreotide retrobulbar injection therapy on thyroid associated ophthalmopathy.

METHODS:Fifty-one cases(96 eyes)with thyroid associated ophthalmopathy were treated with methylprednisolone(500mg/d)for 3d, and then retrobulbar injection of octreotide(0.1mg/mo)for 3mo in one course. Symptoms and signs of the patients were observed before and after the treatment course.

RESULTS: Symptoms of 49 cases were improved significantly. In all cases, the mean value of exophthalmus of the patients was significantly decreased after the treatment by 3.1±1.4mm. The height of palpebral fissure was significantly decreased after the treatment by 2.4±0.9mm, there were statistically significant difference before and after treatment(P<0.05).

COCLUSION:Methylprednisolone with octreotide retrobulbar injection therapy can improve symptoms and signs of the patients with thyroid associated ophthalmopathy with high safety and no obvious side effect.