AIM: To discuss the subjective visual sensation of femtosecond lenticule extraction(FLEx)in treatment of moderate and high myopia and myopic astigmatism for 6mo follow-up, compare the efficacy with standard laser in situ keratomileusis(LASIK)and confirm FLEx had more advantages on improving visual quality after surgery.

METHODS: In a prospective study 86(172 eyes)moderate and high myopia and myopic astigmatism patients were involved. The myopia degree was -3.00～-10.00D, the astigmatism degree ≤-6.00D. Eighty-six eyes were treated with FLEx in group A, and 86 eyes were treated with LASIK in group B. All patients in the treatment group completed the final 6mo of follow-up. The higher-order aberrations and the uncorrected visual acuity(UCVA)and the best spectacle-corrected visual acuity(BSCVA), objective and manifest refractions, results of slit-lamp examination, the side effects, the corneal flap thickness, intraocular tensionare, corneal topography were noted.

RESULTS: All of operations on 172 eyes were successful without severe complications after 6mo follow-up. The total higher order aberration and spherical aberration induced by FLEx were lower than that by LASIK.

CONCLUSION:FLEx for high myopia and myopic astigmatism has obvious superiority in the aspect of improving visual quality.