AIM: To investigate the association between the single nucleotide polymorphisms(SNP)(rs6214 and rs12423791)in IGF-1 and high myopia susceptibility by performing a Meta-analysis.

METHODS: PubMed, EMBASE, and Chinese National Knowledge Infrastructure(up to March 12, 2014)were searched by two authors independently. Crude odds ratios with 95%CIs were used to assess the strength of the associations between SNP rs6214, rs12324791 and high myopia. Statistical analysis was performed using the program RevMan5.2 software(Revman; The Cochrane Collaboration, Oxford, UK)and STATA 12.0 software(Stata Corporation, College Station, TX, USA).

RESULTS: Five case-control studies with involving 2585 patients with high myopia and 3327 controls were included in this Meta-analysis. No statistical evidence of significant association was found in all genetic models of rs6214A/G and rs12324791G/C.

CONCLUSION: This Meta-analysis suggested that the rs6214A/G and rs12324791G/C mutation in the insulin-like growth factor-1 are not significantly associated with high myopia.