Silent information regulator protein 1(SIRT1)is one of the sirtuins and belongs to histone deacetyase. Its activity depends on nicotinamide adenine dinucleotide(NAD⁺)and is regulated by NAD⁺. Experimental and clinical studies have shown the neuro-protective effect of SIRT1 in the pathogenesis of age-related eye diseases. In this review, the relationship between SIRT1 activator and apoptosis in the retinal cells were discussed. The review also points to SIRT1 as a potential therapeutic target for the clinical management of age-related retinal disease.