AIM: To observe the curative effect of PDT combined with intravitreal injection of ranibizumab treatment for age-related macular degeneration with choroidal neovascularization(CNV).

METHODS: In accordance with the inclusion criteria, by indocyanine green choroidalangiography(ICGA)and optical coherence tomography(OCT)examination confirmed the diagnosis of macular CNV in 27 patients(27 eyes), treated with PDT 3～7d professional intravitreal injection of ranibizumab. At 1, 3, 6mo after treatment, the results of best corrected visual acuity(BCVA), FFA, ICGA, OCT examination and complications were observed.

RESULTS: The BCVA improved in 17 eyes(63%), stable in 6 eyes(22%), and decreased in 4 eyes(15%). Before treatment, the average leakage area was 1 005.69±105.47μm, it were 875.54±103.27μm, and 423.37±79.68μm at 1 and 3mo after treatment, there were significant differences compared with before treatment(P<0.01). Average central macular thickness of retina before treatment was 485.58±122.59μm, and 398.84±105.32μm, 297.74±89.18μ m at 1 and 3mo after treatment, there were significant differences compared with before treatment(P<0.01).

CONCLUSION: The method that PDT closed CNV combined with intravitreal injection of ranibizumab can effectively block angiogenesis recurrence, reduce the number of PDT treatment again and complications, improve the therapeutic effect.