AIM:To investigate the relationship of susceptibility of primary angle-closure glaucoma with glutathione S-transferase T1(GSTT1)and M1(GSTM1)polymorphisms.

METHODS: Totally,300 cases were collected from primary angle-closure glaucoma patients and 300 health volunteers were served as control group. The observation group were divided into chronic and acute primary angle-closure glaucoma groups, then multiplex PCR technology was used to detect the genetic polymorphisms of GSTM1 and GSTT1.

RESULTS:The distribution frequencies of GSTT1-null genotype were 54.3%, while it was 54.0% in the control group, statistically no significance between control group and observation group(χ²=0.053, P>0.05); The frequency GSTT1-null genotype in chronic group of primary angle-closure glaucoma was 54.9%, while it was 48.6% in the acute group of primary angle-closure glaucoma, statistically no significance between control group and acute group(χ²=0.064, P>0.05), and chronic group(χ²=0.037, P>0.05); The distribution frequencies of GSTM1-null genotype was 59.0%, while it was 55.7% in the control group, statistically no significance between control group and observation group(χ²=0.013, P>0.05); The distribution frequencies of GSTM1-null genotype was 62.3% and 58.1% in acute and chronic group of primary angle-closure glaucoma patients respectively. Acute group of primary angle-closure glaucoma has no significant compared with control group(χ²=0.005, P>0.05), Chronic group of primary angle-closure glaucoma had no significant compared with control group(χ²=0.047, P>0.05).

CONCLUSION:No statistic significance relationship is found between primary angle-closure glaucom patients and the null genotypes of GSTM1 and GSTT1 susceptibility.