AIM:To observe the efficiency of limbal stem cell transplantation for treatment of limbal papilloma and to explore the treatment methods of limbal papilloma.

METHODS:Prospective study was conducted. Continuous observation was given to the patients who were diagnosed as limbal papilloma at Tongji Hospital from January to December 2014. In this study, a standard excision combined with autologous conjunctival limbal stem cell free flap transplantation was used; pathology examination for specimen was carried out after surgeries for specific pathological diagnosis. Anti-inflammatory, infection-preventing and epithelial repair-promoting medications were given after surgeries. Sutures were removed at 10～14d postoperatively. Before and after surgeries, papilloma lesion were examined using slit lamp microscope photography, anterior segment OCT measurement. All patients were followed up for 6～12mo.

RESULTS:Four patients were included in this study, 3 males and 1 female. Patients aged 48～62 years, mean 55.5±5.8; the diameter of papilloma lesion was 5～12mm, average 8.25±2.99mm; limbal encroachment range was 5～12mm, average 7.25±3.20mm. Post-operative corneal epithelial healing time was 2～5d, an average of 3.25±1.26d. Anterior segment OCT showed no Bowman membrane invasion. No recurrence was observed during follow-up period, no limbal stem cell deficiency was observed in the donor site of limbal stem cell.

CONCLUSION:Simple excision combined with autologous limbal stem cell transplantation is an effective treatment for limbal papilloma.