AIM:To discuss the application of trypan blue before continuous curvilinear capsulorhexis(CCC)during the surgery for all white or over ripe stage cataract.

METHODS:Forty-two eyes in 42 patients with cataract in all white or over ripe stage were selected. During the operations, 0.2mL trypan blue(0.6mg/mL)was injected into the anterior chambers of all the 42 eyes. The anterior capsule was stained to light blue. Then the CCC was conducted. The density of corneal endothelial cells and the percentage of corneal endothelial cells with hexagonal shape were recorded before and at 1wk and 1mo after operations. Repetitive measure analysis of variance was used in analyzing the recording results at different time points.

RESULTS:After stained with trypan blue, CCC was successfully performed in all the operations, which identified a successful basis for the following surgery. There was no significant difference in the density of corneal endothelial cells before and after operations, so as the proportion of corneal endothelial cells with hexagonal shape.

CONCLUSION:After stained with trypan blue, CCC is more feasible and safer for all white and other difficult-to-treat cataract.