Corneal neovascularization(CNV)is caused by the unbalance of corneal avascularity maintaining factors, and then the limbus capillary invades the transparent corneal tissue. CNV is one of the common causes of blindness. In recent years, with the developing of immunology, molecular biology and pharmacology,we have made a lot of breakthroughs about the pathogenesis and treatment of CNV. However, there is no effective medicine and therapy for CNV. In this article we reviewed the pathogenesis, molecular mechanism of CNV, and focus on the progress of therapies.