AIM: To improve the efficiency and quality of teaching, and to cultivate students' ability to analyze and solve clinical problems, the case-based learning(CBL)combined with problem-based learning(PBL)teaching mode is introduced into the clinical teaching of ophthalmology.

METHODS:Two classes(total 131 students)of 2013 grade major in clinical medicine, Kunming Medical University, were randomly selected as experimental group using CBL combined with PBL teaching mode, and control group using traditional teaching mode. The part of acute angle-closure glaucoma was taught. The scores of the experimental group were compared with that of control group at the end of term.

RESULTS: The mean scores of CBL combined with PBL teaching group were significantly higher than that of traditional teaching group.

CONCLUSION: The application of CBL combined with PBL in the clinical teaching of ophthalmology has obvious advantages in improving the learning interests and promoting students' self-learning ability. It is helpful in improving the students' ability of independent-thinking, analyzing and solving problem.