AIM: To investigate the clinical effect of vitamin B₁₂ eye drops for vision fatigue caused by visual display terminals(VDT).

METHODS: Totally 50 patients(100 eyes)with vision fatigue caused by VDT were averagely divided into two groups. The control group were treated with normal saline,the treatment group were treated with vitamin B₁₂ eye drops,3 times per day, one drop each time, continuous for 60d. Accommodative parameters and Schirmer Ⅰtest were measured and analyzed before and after treatment.

RESULTS:After treatment, the results of Schirmer Ⅰtest, accommodative amplitude and accommodative facility of the treatment group were higher than those of the control group(all P<0.05).And the results of accommodation lag of the treatment group were lower than those of the control group(P<0.05).

CONCLUSION: Vitamin B₁₂ eye drops can lessen symptoms of dry eye, improve accommodative function and treat vision fatigue caused by VDT.