AIM: To discuss clinical efficacy and safety of 10g/L atropine with short covering for children with amblyopia.

METHODS: Eighty-eight children(88 eyes)with amblyopia, staying in hospital from February 2011 to February 2014 for treatment, were divided into control group(n=44)and observation group(n=44). The control group only given short covering therapy was observed. Observation group was given 10g/L atropine treatment besides covering. Clinical efficacy, treatment compliance, visual acuity, corrected spherical degree of amblyopia eye and adverse events were observed and compared.

RESULTS: 1)After treatment, total effective rate of the observation group was 95%(42/44), significantly higher than that of control group(80%, 35/44, P<0.05); 2)excellent compliance rate of the observation group was 95%(42/44), significantly higher than that of control group(82%, 36/44, P<0.05); 3)visual acuity of the two groups when the disease was first diagnosed was not significantly different(P>0.05), but increased number of lines of vision and corrected spherical degree of amblyopia eye in the observation group were significantly higher(P<0.05); 4)in the observation group total rate of adverse events was 9%(4/44), significantly lower than that in the control group(23%, 10/44, P<0.05).

CONCLUSION: The combined therapy, 1% atropine with short covering, is effective and safe for amblyopia in children.