AIM: To evaluate the clinical outcomes of combined wavefront-guided and aspheric laser in situ keratomileusis(LASIK)to correct myopia and myopic astigmatism.

METHODS: Prospective study. Forty-five patients(62 eyes)with myopia and myopic astigmatism were randomly dividied into two groups: the wavefront-guided and aspheric LASIK group and the wavefront-guided LASIK group. Safety, efficacy, predictability, ocular higher order aberrations(HOAs), and contrast sensitivity under mesopic condition were compared at 6mo postoperatively.

RESULTS: Both platforms had equal safety, efficacy and predictability. At 6mo after operation, total HOAs, spherical aberration and coma increased in both groups(P<0.01). The changes of total HOAs and spherical aberration in wavefront-guided and aspheric group were significantly less than those in wavefront-guided group(P<0.05), while the change of coma between two groups was not statistically significant(P=0.657).Contrast sensitivity in the wavefront-guided and aspheric group recovered to preoperative levels under mesopic conditions at all spatial frequencies(P>0.05), while contrast sensitivity in the wavefront-guided group recovered to preoperative levels at all spatial frequencies(P>0.05).

CONCLUSION: Wavefront-guided and aspheric LASIK induced less HOAs and associated with better mesopic contrast sensitivity compared with wavefront-guided LASIK.