JNK,which is called the c-Jun N-terminal kinase, is a member of mitogen activated protein kinases, located in cytoplasm. The studies on JNK have been quite active recently. It not only has close connections to cell generation, differentiation and apoptosis, but also plays a crucial role in numerous diseases. This paper expounds the relationship between JNK signaling pathway and extracellular stimuli in the eye structure, and introduces the latest achievement, so as to find the new references for therapy among eye diseases.