Posterior capsule opacification(PCO)is the most common complication after cataract surgery. How to prevent and treat PCO is an urgent problem we need to solve at present. Non-coding RNA(ncRNA)is a kind of RNA, which can not encode proteins. Studies have shown that non-coding RNA is closely related to the occurrence and development of human diseases. This paper has collected the progress of research on different kinds of ncRNA in PCO and may raise new ideas and methods on the prevention and treatment of PCO.