AIM: To observe the effect of nerve growth factor treatment on traumatic optic nerve contusion and evaluate its therapeutic effect.

METHODS: From January 2012 to January 2016, 48 cases(50 eyes)with optic nerve contusion were treated. Retrospective study was carried out and the patients were randomly divided into two groups, treatment group 24 cases of 24 eyes, 26 eyes of 24 cases in the control group; the treatment group mainly used mouse nerve growth factor injection 30μg, 1 times daily intramuscular injection of medication, 6wk, with the application of high pressure hyperbaric oxygen therapy, glucocorticoid and vitamin treatment; the treatment of control group was the same as treatment group, but without the injection of mouse nerve growth factor. Visual acuity, visual evoked potential(VEP)and mean sensitivity(MS), and mean deviation(MD)were examined in all patients at 6wk after the treatment.

RESULTS: After treated for 6wk, there were significant differences in the best corrected visual acuity(P<0.05)between the two groups. VEP P100 latency of treatment group was 98.76±6.93ms, amplitude was 5.22±1.64μV, those of the control group were 116.52±8.82ms, 4.28±1.75μV, both significantly different between the two groups(P<0.05). The differences on MS and MD were significant(P<0.05).

CONCLUSION: The treatment of traumatic optic nerve contusion with nerve growth factor injection has more obvious curative effect.