Ocular complications of HIV infection
Author:
Fund Project:

National Natural Science Foundation of China(No.81460087)

  • Article
  • | |
  • Metrics
  • |
  • Reference [57]
  • |
  • Related [20]
  • | | |
  • Comments
    Abstract:

    In recent years,with the widespread application of highly effective antiretroviral therapy(HAART), the incidence of human immunodeficiency virus(HIV)and acquired immunodeficiency syndrome(AIDS)related eye complications was significantly reduced. The absolute number of patients infected with HIV and AIDS increased year by year, and the survival rate increased and the survival time prolonged. The clinical manifestations of associated ocular complications in these patients are variable, affecting almost all ocular structures. At present, there is a lack of large-scale and long-term systematic observation of eye lesions in HIV-infected and AIDS patients in China. Misdiagnosis and missed diagnosis occur in many hospitals and even in some of the top-three hospitals. This not only delays the treatment of patients, but also easily cause iatrogenic transmission. Therefore, ophthalmologists and even other medical workers should enhance their knowledge of HIV/AIDS. This paper reviews the common complications of non-infection, opportunistic infection, and immune reconstitution inflammatory response syndrome(IRIS)in the HIV/AIDS patients, and discusses the manifestations and research progress of posterior ocular complications of HIV/AIDS.

    Reference
    1 Beyrer C,Shisana O,Baral SD,et al. The science of Durban,AIDS 2016. J Int AIDS Soc 2017; 20(1):21781
    2 Shacklett BL,Derdeyn CA,Folayan MO,et al. HIVR4P 2016,Partnering for Prevention:Conference Summary and Highlights. AIDS Res Hum Retroviruses 2017; 33(8):749-759
    3 Jabs DA,Van Natta ML,Pak JW,et al. Incidence of Intermediate-stage Age-related Macular Degeneration in Patients With Acquired Immunodeficiency Syndrome. Am J Ophthalmol 2017; 179:151-158
    4 Schaftenaar E,Khosa NS,Baarsma GS,et al. HIV-infected individuals on long-term antiretroviral therapy are at higher risk for ocular disease. Epidemiol Infect 2017; 145(12):2520-2529
    5叶俊杰. 重视人类免疫缺陷病毒感染和获得性免疫缺陷综合征的眼部并发症. 中华眼科杂志 2013; 49(3):196-198
    6 Martin-Odoom A,Bonney EY,Opoku DK. Ocular complications in HIV positive patients on antiretroviral therapy in Ghana. BMC Ophthalmol 2016; 16:134
    7 Kassa E,Rinke DWT,Hailu E,et al. Evaluation of the World Health Organization staging system for HIV infection and disease in Ethiopia:association between clinical stages and laboratory markers. AIDS 1999; 13(3):381-389
    8 Port AD,Orlin A,Kiss S,et al. Cytomegalovirus Retinitis:A Review. J Ocul Pharmacol Ther 2017; 33(4):224-234
    9 Jiramongkolchai K,Liu T,Arevalo JF. Peripheral Retinal Neovascularization with Vitreous Hemorrhage in HIV Retinopathy. Case Rep Ophthalmol 2017; 8(2):353-357
    10 Geng S,Ye JJ,Liu L Q,et al. Diagnosis and treatment of eye diseases associated with HIV infection and AIDS. Zhonghua Yan Ke Za Zhi 2009; 45(12):1093-1098
    11 Ashraf DC,May KP,Holland GN,et al. Relationship between Human Immunodeficiency Virus Neuroretinal Disorder and Vision-Specific Quality of Life among People with AIDS. Ophthalmology 2015; 122(12):2560-2567
    12 Jabs DA,Drye L,Van Natta ML,et al. Incidence and long-term outcomes of the human immunodeficiency virus neuroretinal disorder in patients with AIDS. Ophthalmology 2015; 122(4):760-768
    13 Jeng BH,Holland GN,Lowder CY,et al. Anterior segment and external ocular disorders associated with human immunodeficiency virus disease. Surv Ophthalmol 2007; 52(4):329-368
    14 Jabs DA,Ahuja A,Van Natta ML,et al. Long-term Outcomes of Cytomegalovirus Retinitis in the Era of Modern Antiretroviral Therapy:Results from a United States Cohort. Ophthalmology 2015; 122(7):1452-1463
    15 Jabs DA,Van Natta ML,Holbrook JT,et al. Longitudinal study of the ocular complications of AIDS: 1. Ocular diagnoses at enrollment. Ophthalmology 2007; 114(4):780-786
    16 Wang Z,Jia R,Ge S,et al. Ocular complications of human immunodeficiency virus infection in eastern china. Am J Ophthalmol 2012; 153(2):363-369
    17 Holland GN,Vaudaux JD,Jeng SM,et al. Characteristics of untreated AIDS-related cytomegalovirus retinitis.Ⅰ. Findings before the era of highly active antiretroviral therapy(1988 to 1994). Am J Ophthalmol 2008; 145(1):5-11
    18杨娅玲,江睿,何太雯,等. 获得性免疫缺陷综合征合并巨细胞病毒视网膜炎80例患者的临床特点. 中华眼科杂志 2014; 50(3):197-202
    19 Huang G,Jiang Q,Li M,et al. Retrospective study of cytomegalovirus retinitis complicated with acquired immunodeficiency syndrome. Int J Clin Exp Med 2015; 8(6):9537-9542
    20 Mao F,Wu J,Sun H,et al. Frosted branch angiitis in an AIDS patient with cytomegalovirus retinitis. Int J Infect Dis 2016; 52:9-11
    21 Pathanapitoon K,Ausayakhun S,Kunavisarut P,et al. Detection of cytomegalovirus in vitreous,aqueous and conjunctiva by polymerase chain reaction(PCR). J Med Assoc Thai 2005; 88(2):228-232
    22 Reddy AK,Balne PK,Reddy RK,et al. Development and evaluation of loop-mediated isothermal amplification assay for rapid and inexpensive detection of cytomegalovirus DNA in vitreous specimens from suspected cases of viral retinitis. J Clin Microbiol 2010; 48(6):2050-2052
    23叶俊杰,赵家良,刘小伟,等. 获得性免疫缺陷综合征患者眼房水中检测到人类免疫缺陷病毒一例. 中华眼科杂志 2011; 47(5):458-459
    24 Han Y,Wu N,Zhu W,et al. Detection of HIV-1 viruses in tears of patients even under long-term HAART. AIDS 2011; 25(15):1925-1927
    25 Ruiz-Cruz M,Avila-Rios S,Ormsby CE,et al. Cytokine Profiles in Aqueous Humor and Plasma of HIV-infected Individuals with Ocular Syphilis or Cytomegalovirus Retinitis. Ocul Immunol Inflamm 2018; 26(1):74-81
    26 Ozgonul C,Besirli CG. Recent Developments in the Diagnosis and Treatment of Ocular Toxoplasmosis. Ophthalmic Res 2017; 57(1):1-12
    27 Cordeiro CA,Vieira E,Castro VM,et al. T cell immunoregulation in active ocular toxoplasmosis. Immunol Lett 2017; 184:84-91
    28 Jasper S,Vedula SS,John SS,et al. Corticosteroids as adjuvant therapy for ocular toxoplasmosis. Cochrane Database Syst Rev 2017; 1:D7417
    29 Steiner I,Kennedy PG,Pachner AR. The neurotropic herpes viruses:herpes simplex and varicella-zoster. Lancet Neurol 2007; 6(11):1015-1028
    30 Ittner EA,Bhakhri R,Newman T. Necrotising herpetic retinopathies:a review and progressive outer retinal necrosis case report. Clin Exp Optom 2016; 99(1):24-29
    31 Schoenberger SD,Kim SJ,Thorne JE,et al. Diagnosis and Treatment of Acute Retinal Necrosis:A Report by the American Academy of Ophthalmology. Ophthalmology 2017; 124(3):382-392
    32 Holland GN. Standard diagnostic criteria for the acute retinal necrosis syndrome. Executive Committee of the American Uveitis Society. Am J Ophthalmol 1994; 117(5):663-667
    33 Batisse D,Eliaszewicz M,Zazoun L,et al. Acute retinal necrosis in the course of AIDS:study of 26 cases. AIDS 1996; 10(1):55-60
    34陈之昭,张梅. 获得性免疫缺陷综合征的眼部表现. 中华眼科杂志 2005; 41(6):563-571
    35 Alghamdi A,Palich R,Calin R,et al. Atypical ocular manifestation of primary varicella zoster virus infection as the first manifestation of AIDS. AIDS 2016; 30(4):674-676
    36 Turno-Krecicka A,Boratynska M,Tomczyk-Socha M,et al. Progressive outer retinal necrosis in immunocompromised kidney allograft recipient. Transpl Infect Dis 2015; 17(3):400-405
    37 Lo PF,Lim R,Antonakis SN,et al. Progressive outer retinal necrosis:manifestation of human immunodeficiency virus infection. BMJ Case Rep 2015:2015:bcr2014207344
    38 Sfeir M. Cytomegalovirus implicated in a case of progressive outer retinal necrosis(PORN). J Clin Viro 2015; 69:86-90
    39 Rishi E,Govindarajan MV,Biswas J,et al. Syphilitic uveitis as the presenting feature of HIV. Indian J Ophthalmol 2016; 64(2):149-150
    40 Oliver SE,Aubin M,Atwell L,et al. Ocular Syphilis- Eight Jurisdictions,United States,2014-2015. MMWR Morb Mortal Wkly Rep 2016; 65(43):1185-1188
    41 Tsen CL,Chen SC,Chen YS,et al. Uveitis as an initial manifestation of acquired immunodeficiency syndrome. Int J STD AIDS 2017; 28(12):1224-1228
    42张锐,钱江,王朱健,等. 合并人免疫缺陷病毒感染的梅毒性葡萄膜视网膜炎的临床表现. 中华眼科杂志 2015; 51(10):739-745
    43 Kunavisarut P,Sirirungsi W,Pathanapitoon K,et al. Clinical manifestations of human immunodeficiency virus-induced uveitis. Ophthalmology 2012; 119(7):1455-1459
    44王伟伟,叶俊杰. 获得性免疫缺陷综合征并发巨细胞病毒性视网膜炎的药物治疗现状和进展. 中华眼科杂志2010; 46(12):1148-1152
    45 Sun HY,Peng XY,Li D,et al. Cytomegalovirus retinitis in patients with AIDS before and after introduction of HAART in China. Eur J Ophthalmol 2014; 24(2):209-215
    46 Murthy AR,Marulappa R,Hegde U,et al. Treatment guidelines and prognosis of immune reconstitution inflammatory syndrome patients:a review. J Int Oral Health 2015; 7(4):92-95
    47马楠,叶俊杰. 眼免疫重建炎症反应综合征. 中华眼科杂志 2016; 52(2):150-153
    48 French MA,Lenzo N,John M,et al. Immune restoration disease after the treatment of immunodeficient HIV-infected patients with highly active antiretroviral therapy. HIV Med 2000; 1(2):107-115
    49 Karavellas MP,Lowder CY,Macdonald C,et al. Immune recovery vitritis associated with inactive cytomegalovirus retinitis:a new syndrome. Arch Ophthalmol 1998; 116(2):169-175
    50 Yeo TH,Yeo TK,Wong EP,et al. Immune recovery uveitis in HIV patients with cytomegalovirus retinitis in the era of HAART therapy-a 5-year study from Singapore. J Ophthalmic Inflamm Infect 2016; 6(1):41
    51 Kempen JH,Min YI,Freeman WR,et al. Risk of immune recovery uveitis in patients with AIDS and cytomegalovirus retinitis. Ophthalmology 2006; 113(4):684-694
    52 Song MK,Azen SP,Buley A,et al. Effect of anti-cytomegalovirus therapy on the incidence of immune recovery uveitis in AIDS patients with healed cytomegalovirus retinitis. Am J Ophthalmol 2003; 136(4):696-702
    53郝磊,卢宁,王莹. 霜样树枝状视网膜血管炎三例. 中华眼科杂志 2010; 46(1):76-79
    54刘骏杰,黄宝宇,卢淑文,等. 获得性免疫缺陷综合征合并巨细胞病毒性霜样树枝状视网膜血管炎一例. 中华眼底病杂志 2016; 32(5):540-542
    55 Gharai S,Venkatesh P,Garg S,et al. Ophthalmic manifestations of HIV infections in India in the era of HAART:analysis of 100 consecutive patients evaluated at a tertiary eye care center in India. Ophthalmic Epidemiol 2008; 15(4):264-271
    56 Pathai S,Lawn SD,Weiss HA,et al. Increased ocular lens density in HIV-infected individuals with low nadir CD4 counts in South Africa:evidence of accelerated aging. J Acquir Immune Defic Syndr 2013,63(3):307-314
    57叶俊杰,李海燕,孙鼎,等. 获得性免疫缺陷综合征并发巨细胞病毒性视网膜炎的临床分析. 中华眼科杂志2005(09):40-43
    Cited by
    Comments
    Comments
    分享到微博
    Submit
Get Citation

Rong Huang, Hui-Yuan Huang, Yi-Qiao Xing,/et al.Ocular complications of HIV infection. Guoji Yanke Zazhi( Int Eye Sci) 2018;18(8):1411-1415

Copy
Share
Article Metrics
  • Abstract:1851
  • PDF: 1031
  • HTML: 0
  • Cited by: 0
Publication History
  • Received:February 01,2018
  • Revised:June 29,2018
  • Online: July 20,2018