AIM: To study the postoperative incidence and related factors of high intraocular pressure after vitrectomy in patients with proliferative diabetic retinopathy(PDR).

METHODS: Selected in February 2014 to February 2016, 110 cases(160 eyes)of PDR patients were retrospectively analyzed; postoperative vision improvement, high intraocular pressure in patients with different stages of PDR were analyzed and related factors were detected.

RESULTS: Postoperative vision of PDR patients with stage Ⅳ, stage Ⅴ, and stage Ⅵ significantly improved(P<0.01). A total of 47 eyes had high intraocular pressure, in which there were 7 eyes during 1-2mo after operation, 12 eye during 3-4mo, 13 eyes during 5-6mo and, 7 eyes during 7-8mo, 5 eyes during 9-10mo, 3 eyes during 11-12mo, the total incidence was 29.4%. There 21 eyes(44.7%)had controlled IOP after treatment with conventional drugs; IOP of 6 eyes(12.8%)with peripheral iridectomy for recommunication between anterior and posterior chamber returned to normal; IOP of 7 eyes(14.9%)returned to normal after releasing some gas; IOP of 6 eyes(12.8%)returned to normal after taking out some silicone oil; 7 eyes(14.9%)with surgical resection and local glucocorticoid hormone. Preoperative PDR staging, whether preoperative combined with retinal detachment, whether combined with intraoperative lens removal, whether with intraoperative intraocular filling, whether pan retinal photocoagulation were factors associated with postoperative high intraocular pressure(P<0.05). After multiariable Logistic regression analysis, with retinal detachment and intraoperative intraocular filling was independent risk factors for high intraocular pressure after vitrectomy(P<0.05).

CONCLUSION: Retinal detachment, intraoperative joint lens removal, intraoperative intraocular filling, pan retinal photocoagulation is correlated with high intraocular pressure after vitrectomy. Intraoperative joint lens removal, intraoperative intraocular filling and preoperative PDR staging are independent risk factors. In clinical works, standardized and personalized treatment should be given according to the patients' situation trying to avoid the high IOP after vitrectomy.