Silicone oil, as a temporary vitreous substitute, has been widely applied to the treatment of various complex vitreoretinal disease. However, silicone oil tamponade also causes a variety of postoperative complications, the most common of which is temporary or permanent elevated intraocular pressure(IOP). A number of studies have shown that intraocular pressure after silicone oil filling is affected by a variety of factors. In this paper, the progress on the risk factors and pathogenesis of secondary high intraocular pressure after silicone oil tamponade are reviewed, which might provide a reference for the timely and effective control of IOP.