As the morbidity of myopia increasing gradually, the prevention-control of myopia has been given more attentions. Orthokeratology(OK-lens), is now widely approved and used in clinical treatment as a non-surgical measure. The OK-lens directly contact the corneal anterior surface, therefore having some effects on the morphology and biological characteristics of the cornea. The purpose of this paper is to put forward suggestions and advices for clinic, by reviewing the influence of OK-lens on the corneal sub-basal nerve plexus in the current studies.