Herpes simplex viral keratitis(HSK)is caused by herpes simplex virus a serious infective corneal disease. Herpes simplex virus(HSV)infection comes in two forms: primary and recurrent.Between them, the recurrent herpes simplex virus infection way of relevant mechanisms and intervention is the research focus in recent years. In this article, we've introduced the recurrent immune system and treatment of the recurrent herpes of herpes simplex, analysed the newly discovered drugs against herpes simplex virus recurrence, and we're hoping to develop a new form of intervention, a chemical that has a stronger effect and less toxic, so that we can reduce the potential side effects and provide better treatment results.