Effect of Qingguang'an on collagen fiber, alpha-SMA and FN in scar of filter tract after glaucoma surgery

doi:10.3980/j.issn.1672-5123.2019.6.03

Home > Archive>Volume 19, Issue 6, 2019 >906-910. DOI:10.3980/j.issn.1672-5123.2019.6.03

Effect of Qingguang'an on collagen fiber, alpha-SMA and FN in scar of filter tract after glaucoma surgery
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                        10.3980/j.issn.1672-5123.2019.6.03
                    
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Fund Project:National Natural Science Foundation of China(No.81273807, 81603665); Doctoral Program Fund of the Ministry of Education(No.20124323110006); China Postdoctoral Fund Project(No. 2017M612565); National Traditional Chinese Medicine Administration Chinese Medicine Ophthalmology Key Discipline Construction Project; Hunan Provincial Natural Science Fund Key Project(No.11JJ2050, 2017JJ3238); Hunan Provincial Graduate Innovation Fund Key Funding Project(No.CX2013A013); Hunan Provincial High-level Health Talents “225” Project Training Project Funding; Hunan Provincial Traditional Chinese Medicine ENT Science Focus Disciplinary Construction Projects; First Class of Traditional Chinese Medicine, Hunan University of Traditional Chinese Medicine(No.2018ZYX15)

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Abstract:

AIM: To observe the effects on four effective components of Qingguang'an on collagen fibers, α-smooth muscle actin(α-SMA)and fibronectin(FN)in rabbits after glaucoma surgery.

METHODS: Apply four kinds of effective components of Qingguang'an and Qingguang'an Chinese medicine suspension to D, E, F, G, H groups after filtration surgery, and pass with group A(blank control group)and group B(model group)Compared with group C(Mitomycin C group), the effects of four effective components of Qingguang'an and Qingguang'an traditional Chinese medicine suspension on collagen fibers, α-SMA and FN in the scar tissue of glaucoma after filtration were observed.

RESULTS: Compare to B group, the ratio of collagen fiber area to E, F, H group, the expressions of α-SMA and the expressions of FN were different(P<0.05).

CONCLUSION: Qingguang'an effective components 2, Qingguang'an effective components 3, mitomycin C and Qingguang'an suspension reduce the proliferation of myofibroblasts and fibroblasts by inhibiting the expression of collagen fibers, α-SMA and FN, and showed obvious anti-glaucoma staining scar after surgery.

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Xue-Si Huang, Jun Peng, Peng-Fei Jiang, et al. Effect of Qingguang'an on collagen fiber, alpha-SMA and FN in scar of filter tract after glaucoma surgery. Guoji Yanke Zazhi( Int Eye Sci) 2019;19(6):906-910

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Received:October 11,2018
Revised:May 07,2019
Adopted:
Online: May 22,2019
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