Retinal pigment epithelium(RPE)plays an important role in maintaining the normal physiological function of photoreceptors and other retinal cells. The pathological changes of RPE can cause the occurrence and development of many retinal diseases. It was reported rencently that there are differential expressions of long noncoding RNAs(LncRNAs)in ophthalmic eye diseases, which play important roles in the pathogenesis of different types of eye diseases. It indicated that LncRNAs may be new targets for gene diagnosis and treatment of ocular diseases. RPE cell is important for retinal function. It will find a novel way for the diagnosis and treatment of retinal diseases if we investigate RPE from the perspective of LncRNA.