AIM:To systematically review the risk factors of age-related macular degeneration(ARMD)in China.

METHODS:PubMed, EMbase, Web of Science, The Cochrane Library, CBM, CNKI, Wan Fang Data VIP databases were electronically searched to collect case-control studies, cohort studies and cross-sectional studies on the risk factors of ARMD in China from inception to December, 2019. Two reviewers independently screened literature, extracted data and assessed risk of bias of included studies, then, Meta-analysis was performed by using RevMan 5.3 software.

RESULTS: A total of 27 studies involving 204 767 objects and 10 risk factors were included. The results of Meta-analysis showed that smoking \〖OR=2.30, 95%CI (1.95, 2.71), P<0.0001\〗, hypertension \〖OR=1.55, 95%CI (1.23, 1.95), P=0.0002\〗, HTRA1 rs11200638\〖OR=4.35, 95%CI (2.35, 7.48), P<0.0001\〗, CFH Y402H \〖OR=3.28, 95%CI (2.51, 4.28), P<0.00001\〗, LOC387715 rs10490924 \〖OR=7.09, 95%CI (3.48, 14.44), P<0.00001\〗. Desciptive analysis results showed that DR, Cataract surgery, NO₂, CO and HBV infection were risk factors of ARMD in China.

CONCLUSION: Current evidence shows that smoking, hypertension, HTRA1 rs11200638, CFH Y402H, LOC387715 rs10490924, DR, cataract surgery, NO₂, CO and HBV infection are the risk factors of ARMD in China.