Research progress of photoreceptor transplantation in retinal degenerative diseases
Author:
Fund Project:

National Natural Science Foundation of China(No.81660158)

  • Article
  • | |
  • Metrics
  • |
  • Reference [31]
  • |
  • Related [20]
  • | | |
  • Comments
    Abstract:

    Retinal degenerative disease is a major disease that affects human vision. It damages human photoreceptor cells and damages human vision. And the mammalian retina does not have the ability to regenerate, once the disease will seriously affect people's normal life. At present, there is no clear way to prevent and alleviate these diseases, but the transplantation of photoreceptors to supplement the damaged photoreceptors in the retina can treat retinal diseases. In this paper, we will discuss the current situation and techniques of photoreceptor transplantation to restore vision in retinal degenerative diseases.

    Reference
    1 Pascolini D, Mariotti SP. Global estimates of visual impairment: 2010. Br J Ophthalmol 2012; 96(5):614-618
    2 Li JQ, Welchowski T, Schmid M, et al. Incidence of rhegmatogenous retinal detachment in Europe - A systematic review and meta-analysis. Ophthalmologica 2019; 242(2):81-86
    3 Masland RH. The neuronal organization of the Retina. Neuron 2012; 76(2):266-280
    4 Strauss O. The retinal pigment epithelium in visual function. Physiol Rev 2005; 85(3):845-881
    5 Bringmann A, Pannicke T, Grosche J, et al. Müller cells in the healthy and diseased Retina. Prog Retin Eye Res 2006; 25(4):397-424
    6 Roska B, Sahel JA. Restoring vision. Nature 2018; 557(7705):359-367
    7 Ehlken C, Jungmann S, Böhringer D, et al. Switch of anti-VEGF agents is an option for nonresponders in the treatment of AMD. Eye(Lond) 2014; 28(5):538-545
    8 Pennesi ME, Weleber RG, Yang P, et al. Results at 5 years after gene therapy for RPE65-deficient retinal dystrophy. Hum Gene Ther 2018; 29(12):1428-1437
    9 da Cruz L, Fynes K, Georgiadis O, et al. Phase 1 clinical study of an embryonic stem cell-derived retinal pigment epithelium patch in age-related macular degeneration. Nat Biotechnol 2018; 36(4):328-337
    10 Gasparini SJ, Llonch S, Borsch O, et al. Transplantation of photoreceptors into the degenerative retina: Current state and future perspectives. Prog Retin Eye Res 2019; 69:1-37
    11 Smiley S, Nickerson PE, Comanita L, et al. Corrigendum: Establishment of a cone photoreceptor transplantation platform based on a novel cone-GFP reporter mouse line. Sci Rep 2016; 6:24012
    12 Gust J, Reh TA. Adult donor rod photoreceptors integrate into the mature mouse Retina. Invest Ophthalmol Vis Sci 2011; 52(8):5266-5272
    13 Singh MS, Charbel Issa P, Butler R, et al. Reversal of end-stage retinal degeneration and restoration of visual function by photoreceptor transplantation. Proc Natl Acad Sci USA 2013; 110(3):1101-1106
    14 Banin E, Obolensky A, Idelson M, et al. Retinal incorporation and differentiation of neural precursors derived from human embryonic stem cells. Stem Cells 2006; 24(2):246-257
    15 Ikeda H, Osakada F, Watanabe K, et al. Generation of Rx+/Pax6+ neural retinal precursors from embryonic stem cells. Proc Natl Acad Sci USA 2005; 102(32):11331-11336
    16 Lakowski J, Baron M, Bainbridge J, et al. Cone and rod photoreceptor transplantation in models of the childhood retinopathy Leber congenital amaurosis using flow-sorted Crx-positive donor cells. Hum Mol Genet 2010; 19(23):4545-4559
    17 Santos-Ferreira T, Postel K, Stutzki H, et al. Daylight vision repair by cell transplantation. Stem Cells 2015; 33(1):79-90
    18 Peng YQ, Tang LS, Zhou YD. Subretinal injection: a review on the novel route of therapeutic delivery for vitreoretinal diseases. Ophthalmic Res 2017; 58(4):217-226
    19 Eberle D, Kurth T, Santos-Ferreira T, et al. Outer segment formation of transplanted photoreceptor precursor cells. PLoS One 2012; 7(9):e46305
    20 Ballios BG, Cooke MJ, van der Kooy D, et al. A hydrogel-based stem cell delivery system to treat retinal degenerative diseases. Biomaterials 2010; 31(9):2555-2564
    21 del Cerro M, Gash DM, Rao GN, et al. Intraocular retinal transplants. Invest Ophthalmol Vis Sci 1985; 26(8):1182-1185
    22 Seiler MJ, Aramant RB. Intact sheets of fetal Retina transplanted to restore damaged rat retinas. Invest Ophthalmol Vis Sci 1998; 39(11):2121-2131
    23 Radtke ND, Aramant RB, Petry HM, et al. Vision improvement in retinal degeneration patients by implantation of Retina together with retinal pigment epithelium. Am J Ophthalmol 2008; 146(2):172-182
    24 Foik AT, Lean GA, Scholl LR, et al. Detailed visual cortical responses generated by retinal sheet transplants in rats with severe retinal degeneration. J Neurosci 2018; 38(50):10709-10724
    25 West EL, Pearson RA, Barker SE, et al. Long-term survival of photoreceptors transplanted into the adult murine neural Retina requires immune modulation. Stem Cells 2010; 28(11):1997-2007
    26 Zarbin M. Cell-based therapy for degenerative retinal disease. Trends Mol Med 2016; 22(2):115-134
    27 Barber AC, Hippert C, Duran, et al. Repair of the degenerate Retina by photoreceptor transplantation. Proc Natl Acad Sci USA 2013; 110(1):354-359
    28 Assawachananont J, Mandai M, Okamoto S, et al. Transplantation of embryonic and induced pluripotent stem cell-derived 3D retinal sheets into retinal degenerative mice. Stem Cell Rep 2014; 2(5):662-674
    29 Jung YH, Phillips MJ, Lee J, et al. 3D microstructured scaffolds to support photoreceptor polarization and maturation. Adv Mater 2018; 30(39):e1803550
    30 Lavik EB, Klassen H, Warfvinge K, et al. Fabrication of degradable polymer scaffolds to direct the integration and differentiation of retinal progenitors. Biomaterials 2005; 26(16):3187-3196
    31 DiCarlo JE, Mahajan VB, Tsang SH. Gene therapy and genome surgery in the Retina. J Clin Invest 2018; 128(6):2177-2188
    Cited by
    Comments
    Comments
    分享到微博
    Submit
Get Citation

Chao Yu, Qiu-Yu Li, Yi Shao. ,/et al.Research progress of photoreceptor transplantation in retinal degenerative diseases. Guoji Yanke Zazhi( Int Eye Sci) 2021;21(7):1175-1178

Copy
Share
Article Metrics
  • Abstract:792
  • PDF: 1467
  • HTML: 0
  • Cited by: 0
Publication History
  • Revised:May 28,2021
  • Online: June 24,2021