Diabetic retinopathy(DR)is one of the most common chronic microvascular complications of diabetes. Due to its complex pathogenesis, DR has been an extensively international investigated topic over the past few decades. Neurodegeneration, inflammation and vascular alternately regeneration and injury could promote pathogenesis of DR. Recently more and more evidence showed that DR retinal chronic low rate could be a key factor in DR, which is a more early manifestation of DR. However, the exact molecular mechanism of its inflammation is not still clear so far. In this article, we will review the role of inflammation and its intervention mechanism in DR.