Research progress on biomarkers of pseudoexfoliative glaucoma
Author:
Fund Project:

Science and Technology Plan Project of Yunnan Provincial Department of Science and Technology(No.202201AT070073); Yunnan Basic Research Special Project Kunming Medical Union Special Project(No.202001AY070001-165)

  • Article
  • | |
  • Metrics
  • |
  • Reference [1]
  • |
  • Related [20]
  • | | |
  • Comments
    Abstract:

    Pseudoexfoliative glaucoma(PEXG)is an eye disease that seriously endangers vision. It is more invasive than primary open-angle glaucoma(POAG), with more serious damage to the optic nerve, worse prognosis and higher resistance to treatment. Early diagnosis of PEXG can help to treat the disease in time and delay the progress of the disease, so it is important to determine appropriate biomarkers. In recent years, more and more people have begun to study the biomarkers of PEXG, hoping to understand the pathogenesis of the disease, find out the potential early diagnosis and treatment targets of PEXG, and provide some help to the disease through the research of genomics, transcriptomics, proteomics, metabolomics and lipomics markers. This article will review the progress of biomarkers of PEXG in recent years, some biomarkers may provide new ideas for early diagnosis of PEXG in the future.

    Reference
    1 Tham YC, Li X, Wong TY, et al. global prevalence of glaucoma and projections of glaucoma burden through 2040:a systematic review and meta-analysis. Ophthalmology 2014; 121(11):2081-2090<br>2 Kapuganti RS, Mohanty PP, Alone DP. Quantitative analysis of circulating levels of vimentin, clusterin and fibulin-5 in patients with pseudoexfoliation syndrome and glaucoma. Exp Eye Res 2022; 224:109236<br>3 Chakraborty M, Rao A. Alternate causes for pathogenesis of exfoliation glaucoma, a multifactorial elastotic disorder: a literature review. Curr Issues Mol Biol 2022; 44(3):1191-1202<br>4 Tekin K, Inanc M, Elgin U. Monitoring and management of the patient with pseudoexfoliation syndrome: current perspectives. Clin Ophthalmol 2019; 13:453-464<br>5 Gillmann K, Meduri E, Niegowski LJ, et al. Surgical management of pseudoexfoliative glaucoma: a review of current clinical considerations and surgical outcomes. J Glaucoma 2021; 30(3):e32-e39<br>6 Kimura A, Namekata K, Guo XL, et al. Targeting oxidative stress for treatment of glaucoma and optic neuritis. Oxid Med Cell Longev 2017; 2017:2817252<br>7 Li Z, Allingham RR, Nakano M, et al. A common variant near TGFBR3 is associated with primary open angle glaucoma. Hum Mol Genet 2015; 24(13):3880-3892<br>8 Shiga Y, Akiyama M, Nishiguchi KM, et al. Genome-wide association study identifies seven novel susceptibility loci for primary open-angle glaucoma. Hum Mol Genet 2018; 27(8):1486-1496<br>9 Springelkamp H, Mishra A, Hysi PG, et al. Meta-analysis of genome-wide association studies identifies novel loci associated with optic disc morphology. Genet Epidemiol 2015; 39(3):207-216<br>10 Springelkamp H, Iglesias AI, Mishra A, et al. New insights into the genetics of primary open-angle glaucoma based on meta-analyses of intraocular pressure and optic disc characteristics. Hum Mol Genet 2017; 26(2):438-453<br>11 Kasetti RB, Maddineni P, Patel PD, et al. Transforming growth factor β2(TGFβ2)signaling plays a key role in glucocorticoid-induced ocular hypertension. J Biol Chem 2018; 293(25):9854-9868<br>12 Iglesias AI, Springelkamp H, van der Linde H, et al. Exome sequencing and functional analyses suggest that SIX6 is a gene involved in an altered proliferation-differentiation balance early in life and optic nerve degeneration at old age. Hum Mol Genet 2014; 23(5):1320-1332<br>13 Eliseeva N, Ponomarenko I, Reshetnikov E, et al. The haplotype of the CDKN2B-AS1 gene is associated with primary open-angle glaucoma and pseudoexfoliation glaucoma in the Caucasian population of Central Russia. Ophthalmic Genet 2021; 42(6):698-705<br>14 Chen W, Yang AT, Jia JD, et al. Lysyl oxidase(LOX)family members: rationale and their potential as therapeutic targets for liver fibrosis. Hepatology 2020; 72(2):729-741<br>15 Greene AG, Eivers SB, Dervan EWJ, et al. Lysyl Oxidase Like 1:biological roles and regulation. Exp Eye Res 2020; 193:107975<br>16 Vallabh NA, Sambare C, Muszynska-Lyons D, et al. Prevalence of risk alleles in the lysyl oxidase-like 1 gene in pseudoexfoliation glaucoma patients in India. Indian J Ophthalmol 2022; 70(6):2024-2028<br>17 Papadopoulou MK, Chatziralli I, Tzika K, et al. Correlation of the intronic LOXL1 polymorphism rs11638944 with pseudoexfoliation syndrome and glaucoma in a Greek population. Ophthalmic Genet 2021; 42(4):405-411<br>18兰兰, 雷方. 剥脱型青光眼LOXL1基因多态性分析. 实验与检验医学 2020; 38(3): 423-425,429<br>19 Eivers SB, Greene AG, Dervan E, et al. Prevalence of pseudoexfoliation glaucoma risk-associated variants within lysyl oxidase-like 1 in an Irish population. J Glaucoma 2020; 29(6):417-422<br>20 Greene AG, Eivers SB, McDonnell F, et al. Differential Lysyl oxidase like 1 expression in pseudoexfoliation glaucoma is orchestrated via DNA methylation. Exp Eye Res 2020; 201:108349<br>21 Berner D, Hoja U, Zenkel M, et al. The protective variant rs7173049 at LOXL1 locus impacts on retinoic acid signaling pathway in pseudoexfoliation syndrome. Hum Mol Genet 2019; 28(15):2531-2548<br>22 Yaman D, Takmaz T, Yüksel N, et al. Evaluation of silent information regulator T(SIRT)1 and Forkhead Box O(FOXO)transcription factor 1 and 3a genes in glaucoma. Mol Biol Rep 2020; 47(12):9337-9344<br>23 Ji J, Tao PY, Wang Q, et al. SIRT1:mechanism and protective effect in diabetic nephropathy. Endocr Metab Immune Disord Drug Targets 2021; 21(5):835-842<br>24 Hori YS, Kuno A, Hosoda R, et al. Regulation of FOXOs and p53 by SIRT1 modulators under oxidative stress. PLoS One 2013; 8(9):e73875<br>25 Fakhraie G, Parvini F, Ghanavi J, et al. Association of IL-10 gene promoter polymorphisms with susceptibility to pseudoexfoliation syndrome, pseudoexfoliative and primary open-angle glaucoma. BMC Med Genet 2020; 21(1):32<br>26 Kondkar AA, Sultan T, Azad TA, et al. Evaluation of ABCA1 and FNDC3B gene polymorphisms associated with pseudoexfoliation glaucoma and primary angle-closure glaucoma in a Saudi cohort. Front Genet 2022; 13:877174<br>27 Babashamsi MM, Halalkhor S, Moradi Firouzjah H, et al. Association of ATP-Binding Cassette Transporter A1(ABCA1)-565 C/T Gene Polymorphism with Hypoalphalipoproteinemia and Serum Lipids, IL-6 and CRP Levels. Avicenna J Med Biotechnol 2017; 9(1): 38-43<br>28 Prendes MA, Harris A, Wirostko BM, et al. The role of transforming growth factor β in glaucoma and the therapeutic implications. Br J Ophthalmol 2013; 97(6):680-686<br>29 Katagiri T, Watabe T. Bone morphogenetic proteins. Cold Spring Harb Perspect Biol 2016; 8(6):a021899<br>30 Gomez-Puerto MC, Iyengar PV, García de Vinuesa A, et al. Bone morphogenetic protein receptor signal transduction in human disease. J Pathol 2019; 247(1):9-20<br>31 Kondkar AA, Sultan T, Azad TA, et al. Association analysis of polymorphisms rs12997 in ACVR1 and rs1043784 in BMP6 genes involved in bone morphogenic protein signaling pathway in primary angle-closure and pseudoexfoliation glaucoma patients of Saudi origin. BMC Med Genet 2020; 21(1):145<br>32 Rao A, Padhy D, Sahay P, et al. Clinical spectrum of pseudoexfoliation syndrome-An electronic records audit. PLoS One 2017; 12(10):e0185373<br>33 Liu YM, Chen Y, Wang YY, et al. MicroRNA profiling in Glaucoma eyes with varying degrees of optic neuropathy by using next-generation sequencing. Invest Ophthalmol Vis Sci 2018; 59(7):2955-2966<br>34 Rao A, Chakraborty M, Roy A, et al. Differential miRNA expression: signature for glaucoma in pseudoexfoliation. Clin Ophthalmol 2020; 14:3025-3038<br>35 Kosior-Jarecka E, Czop M, Gasińska K, et al. MicroRNAs in the aqueous humor of patients with different types of glaucoma.Graefes Arch Clin Exp Ophthalmol2021; 259(8):2337-2349<br>36 Sahay P, Chakraborty M, Rao A. Global and comparative proteome signatures in the lens capsule, trabecular meshwork, and Iris of patients with pseudoexfoliation glaucoma. Front Mol Biosci 2022; 9:877250<br>37 Georgakopoulos-Soares I, Chartoumpekis DV, Kyriazopoulou V, et al. EMT factors and metabolic pathways in cancer. Front Oncol 2020; 10:499<br>38 Faralli JA, Filla MS, Peters DM. Role of fibronectin in primary open angle glaucoma. Cells 2019; 8(12):1518<br>39 Sahay P, Reddy S, Prusty BK, et al. TGFβ1, MMPs and cytokines profiles in ocular surface: possible tear biomarkers for pseudoexfoliation. PLoS One 2021; 16(4):e0249759<br>40 Musiani D, Konda JD, Pavan S, et al. Heat-shock protein 27(HSP27, HSPB1)is up-regulated by MET kinase inhibitors and confers resistance to MET-targeted therapy. FASEB J 2014; 28(9):4055-4067<br>41 Reinehr S, Mueller-Buehl AM, Tsai T, et al. Specific biomarkers in the aqueous humour of glaucoma patients. Klin Monbl Augenheilkd 2022; 239(2):169-176<br>42 Beutgen VM, Pfeiffer N, Grus FH. Serological levels of anti-clathrin antibodies are decreased in patients with pseudoexfoliation glaucoma. Front Immunol 2021; 12:616421<br>43 Tang BH, Li SJ, Cao WJ, et al. The association of oxidative stress status with open-angle glaucoma and exfoliation glaucoma: a systematic review and meta-analysis. J Ophthalmol 2019; 2019:1803619<br>44 Yao YS, Wang YB, Zhang YB, et al. Klotho ameliorates oxidized low density lipoprotein(ox-LDL)-induced oxidative stress via regulating LOX-1 and PI3K/Akt/eNOS pathways. Lipids Health Dis 2017; 16(1):77<br>45 Tokuc EO, Yuksel N, Kır HM, et al. Evaluation of serum and aqueous humor klotho levels in pseudoexfoliation syndrome, pseudoexfoliation and primary open-angle glaucoma. Int Ophthalmol 2021; 41(7):2369-2375<br>46 Köhle A, Gülkesen A, Kaya Karata瘙塂 T, et al. Serum netrin-1 and netrin receptor levels in fibromyalgia and osteoarthritis. Turk J Phys Med Rehabil 20221; 68(2):238-245<br>47 Okutucu M, Findik H, Aslan MG, et al. Is netrin-1 deficiency responsible for inflammation and systemic diseases related to pseudoexfoliation? J Glaucoma 2020; 29(11):1077-1081<br>48 Kondkar A, Azad TA, Almobarak F, et al. Elevated levels of plasma tumor necrosis factor alpha in patients with pseudoexfoliation glaucoma. Clin Ophthalmol 2018; 12:153-159<br>49 Can Demirdö(ˇoverg)en B, Demirkaya-Budak S, Özge G, et al. Evaluation of tear fluid and aqueous humor concentration of clusterin as biomarkers for early diagnosis of pseudoexfoliation syndrome and pseudoexfoliative glaucoma. Curr Eye Res 2020; 45(7):805-813<br>50 Yavrum F, Elgin U, Kocer ZA, et al. Evaluation of aqueous humor and serum clusterin levels in patients with glaucoma. BMC Ophthalmol 2021; 21(1):25<br>51Eraslan N,Elgin U,瘙塁en E, et al.Comparison of total/active ghrelin levels in primary open angle glaucoma, pseudoexfoliation glaucoma and pseudoexfoliation syndrome. Int J Ophthalmol 2018; 11(5):823-827<br>52董宇, 胡元会, 何健, 等. 脂质组学在心脑血管疾病研究中的应用及对中医药研究的启示. 世界科学技术(中医药现代化)2022; 24(6):2487-2494<br>53 Myer C, Abdelrahman L, Banerjee S, et al. Aqueous humor metabolite profile of pseudoexfoliation glaucoma is distinctive. Mol Omics 2020; 16(5):425-435<br>54 Cetinkaya E, Duman R, Sabaner MC, et al. Evaluation of thiol-disulfide homeostasis in pseudoexfoliation glaucoma and primary open-angle glaucoma. Niger J Clin Pract 2020; 23(10):1401-1406<br>55 Elbay A, Ozer OF, Altinisik M, et al. A novel tool reflecting the role of oxidative stress in the cataracts: thiol/disulfide homeostasis. Scand J Clin Lab Investig 2017; 77(3):223-227<br>56 Ergan E, Ozturk F, Beyazyildiz E, et al. Oxidant/antioxidant balance in the aqueous humor of patients with glaucoma. Int J Ophthalmol 2016; 9(2):249-252<br>57 Zenkel M, Hoja U, Gießl A, et al. Dysregulated retinoic acid signaling in the pathogenesis of pseudoexfoliation syndrome. Int J Mol Sci 2022; 23(11):5977<br>58 Cabrerizo J, Urcola JA, Vecino E. Changes in the lipidomic profile of aqueous humor in open-angle glaucoma. J Glaucoma 2017; 26(4):349-355<br>59 Edwards G, Arcuri J, Wang HY, et al. Endogenous ocular lipids as potential modulators of intraocular pressure. J Cell Mol Med 2020; 24(7):3856-3900<br>60 Yang K, Han XL. Lipidomics: techniques, applications, and outcomes related to biomedical sciences. Trends Biochem Sci 2016; 41(11):954-969<br>61 Collao V, Morris J, Chauhan MZ, et al. Analyses of pseudoexfoliation aqueous humor lipidome. Mol Omics 2022; 18(5):387-396
    Cited by
    Comments
    Comments
    分享到微博
    Submit
Get Citation

Yue Huang, Yan Li, Zheng-Yi-Lin Bao,/et al.Research progress on biomarkers of pseudoexfoliative glaucoma. Guoji Yanke Zazhi( Int Eye Sci) 2023;23(7):1134-1138

Copy
Share
Article Metrics
  • Abstract:3404
  • PDF: 1024
  • HTML: 0
  • Cited by: 0
Publication History
  • Received:July 26,2022
  • Revised:June 01,2023
  • Online: June 21,2023