Home > Archive>Volume 24, Issue 3, 2024 >375-379. DOI:10.3980/j.issn.1672-5123.2024.3.08
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Role of sex hormones in keratoconus and potential therapeutic targets
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Natural Science Foundation of Henan Province(No.222300420536); Henan Provincial Medical Science Building Key Program(No.SBGJ202002028); Henan Young Health Science and Technology Innovation Outstanding Program(No.YXKC2020023); Special Program for Basic Research of Henan Eye Hospital(No.20JCZD003)

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    Abstract:

    Keratoconus is a blinding corneal disease characterized by central or paracentral corneal thinning and conical ectasia, and usually happens in adolescence. Currently, the etiology of keratoconus is unclear. Multiple studies have identified an association between genetics, eye rubbing, allergic diseases, ultraviolet exposure and keratoconus. Recently, several studies identified that sex hormones also played important roles in the pathogenesis of keratoconus. The disturbance of sex hormones may increase the risk of occurrence and progress of keratoconus. This review aims to summarize the pathophysiological effects of sex hormones on the cornea, clarify the effects of sex hormones on keratoconus and its related inflammatory or immune mechanisms, and explore the role of sex hormones in the early diagnosis and treatment of keratoconus, providing reference and help for clinical work.

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Yuan Yi, Xu Liyan, Yang Kaili,/et al.Role of sex hormones in keratoconus and potential therapeutic targets. Guoji Yanke Zazhi( Int Eye Sci) 2024;24(3):375-379

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Publication History
  • Received:July 14,2023
  • Revised:January 18,2024
  • Online: February 23,2024
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