Home > Archive>Volume 24, Issue 7, 2024 >1064-1067. DOI:10.3980/j.issn.1672-5123.2024.7.10
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Research progress on the relationship between miRNA and pathogenesis of cataract
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National Natural Science Foundation of China(No.82000926); Gansu Health Industry Scientific Research Project(No.GSWSKY2022-05); Fund Project of the 940th Hospital of Joint Service Support Forces of the Chinese People's Liberation Army(No.2021yxky033, 2023YXKY011, 2023YXKY033)

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    Abstract:

    The microRNA(miRNA)is a widely present small non-coding RNA(ncRNA), with a length of 20-25 nucleotides. The miRNA in eye tissue plays crucial roles in normal eyes by participating in processes such as cell growth, proliferation, differentiation, and apoptosis. Cataracts are the main cause of blindness worldwide. Research has shown that miRNA is related to the occurrence and development of cataracts, and it has new application prospects as a potential target for the treatment and prevention of cataracts. This article reviews the relationship between miRNA and the occurrence and development of cataracts through several different pathogenesis mechanisms, including oxidative damage, apoptosis, autophagy, and epithelial mesenchymal transition(EMT).

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Jin Lu, Lyu Yang. ,/et al.Research progress on the relationship between miRNA and pathogenesis of cataract. Guoji Yanke Zazhi( Int Eye Sci) 2024;24(7):1064-1067

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Publication History
  • Received:October 19,2023
  • Revised:May 17,2024
  • Online: June 24,2024
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