The vitrectomy, one of the most popular procedures in ophthalmology, is regarded as a significant advancement in the field. Its functions include restoring transparent refractive media, encouraging retinal reattachment, cutting the patient's turbid vitreous, or removing the traction of the vitreous retina. The goal of treating vitreoretinal illnesses is to enhance the patient's visual function. Nowadays, absorbable sutures, which can be absorbed for around 1 mo, are used frequently to close scleral incisions during vitreous surgery. It can easily lead to infection, idiopathic scleritis, foreign body sensation, and other side effects. The benefits and drawbacks of several novel techniques for closing scleral incisions during vitrectomy are discussed in this research. Through an examination of the aforementioned novel techniques in visual acuity, intraocular pressure, subconjunctival hemorrhage, and complications(endophthalmitis, choroidal effusion/hemorrhage, etc.), the goal is to bolster the efficacy and safety of the recently developed scleral incision closure technique and enhance its application in clinical settings, enabling physicians to optimize surgical outcomes while minimizing collateral damage.