AIM:To investigate the relationship between higher-order aberration (HOA) and myopic progression in school children.METHODS:Between April 23, 2011 and August 29, 2011 in the children’s myopia outpatient clinic of the West China Hospital of Sichuan University, 148 eyes of 74 schoolchildren were reviewed. HOAs for a 6-mm pupil were measured with an aberrometer. Myopic progression rate was defined according to the change in spherical equivalent refraction (SER) divided by the time span (years). Subjects with myopic progression rate of ≥0.50 diopters (D) were classified as the ‘fast’ group and the subjects with myopic progression rate of <0.50D were classified as the ‘slow’ group. A retrospective study was conducted to compare HOA between the two groups, using root mean square (RMS) values and Zernike coefficients.RESULTS: The RMS values of HOA (t=2.316, P=0.02), HOA without Z4⁰ (t=2.224, P=0.03), third-order aberrations (t’=2.62, P=0.01), and coma (t’=2.49, P=0.01) were significantly higher in the fast group than those in the slow group. The individual Zernike coefficients of Z3^-1 (t=-2.072, P=0.04) and Z5¹ (Z =-2.627, P=0.01) displayed statistically significant differences between the two groups. Significant correlations were found between the RMS values of HOA (r=0.193, P=0.019), RMS values of HOA without Z4⁰ (r=0.23, P =0.005), RMS values of coma (r=0.235, P=0.004), RMS values of third-order aberrations (r=0.243, P =0.003), and the progression rate.CONCLUSION:Our results provide evidence of a relationship between HOA and myopic progression. In a future prospective longitudinal study, we aim to verify whether HOA is a risk factor for myopic progression.