AIM:To evaluate the central corneal thickness (CCT) measurements of premature infantsMETHODS: The premature infants who were born between 25-34wk of gestational age (GA) were retrieved for the study. All CCT measurements were performed within the first 2d of their life under topical anesthesia by using an ultrasonic pachymeter.RESULTS: The mean CCT of 200 eyes was 647.79±63.94 μm. The mean CCT of the right and left eyes were similar (647.30±64.72 μm and 648.29±63.47 μm consecutively). The mean CCT of the girls was 642.08±54.89 μm and the boys was 653.07±71.14 μm, with no statistically significant difference (P>0.05). But there was a negative correlation of the CCT with GA and birth weight (BW) (P<0.01).CONCLUSION:The CCT values of premature babies were negatively correlated with GA and BW.