AIM: To evaluate the interchangeability of keratometric and asphericity measurements provided by three measurement systems based on different optical principles. METHODS: A total of 40 eyes of 40 patients with a mean age of 34.1y were included. In all cases, a corneal curvature analysis was performed with IOL-Master (IOLM), iDesign 2 (ID2), and Sirius systems (SIR). Differences between instruments for flattest (K1) and steepest (K2) keratometric readings, as well as for magnitude and axis of corneal astigmatism were analyzed. Likewise, differences in asphericity (Q) between SIR and ID2 were also evaluated. RESULTS: Mean differences between devices for K1 were 0.20±0.21 (P<0.001), -0.12±0.36 (P=0.046) and -0.32±0.36 D (P<0.001) for the comparisons IOLM-SIR, IOLM-ID2 and SIR-ID2, respectively. The ranges of agreement for these comparisons between instruments were 0.41, 0.70, and 0.70 D. For K2, mean differences were 0.31±0.33 (P<0.001), -0.08±0.43 (P=0.265) and -0.39±0.38 D (P<0.001), with ranges of agreement of 0.65, 0.84, and 0.74 D. Concerning magnitude of astigmatism, ranges of agreement were in the limit of clinical relevance (0.49 D, P=0.011; 0.55 D, P=0.386; 0.43 D, P=0.05). In contrast, ranges of agreement were clinically relevant for astigmatic axis (26.68o, 33.83o and 18.37o, P≥0.121) and for Q between SIR and ID2 (0.16, P<0.001). CONCLUSION: The keratometric corneal power, astigmatic axis and asphericity measurements provide by the three systems evaluated cannot be considered as interchangeable, whereas measurements of corneal astigmatism obtained with SIR and ID2 can be considered as interchangeable for clinical purposes.