Home > Archive>Volume 13, Issue 5, 2020 >816-821. DOI:10.18240/ijo.2020.05.18
HTML XML Export Cite reminder
Progress in the basic and clinical research on the Schlemm’s canal
Author:
Corresponding Author:

Qing-Feng Liang. Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Key Laboratory of Ophthalmology and Visual Sciences, Beijing 100005, China. lqflucky@163.com

Fund Project:

Supported by the National Key R&D Program of China (No.2017YFB1302703).

  • Article
    • | |
  • Metrics
    • |
  • Reference
    • |
  • Related
    • | | |
  • Comments
    Abstract:

    Glaucoma is a leading cause of irreversible blindness in the world. Intraocular pressure (IOP) plays a key role in glaucoma development and progression. Schlemm’s canal (SC), an important structure of the anterior chamber angle, regulates the flow of aqueous humor and maintains IOP. Because of its special function of aqueous outflow, the SC has been intensive investigated recently. Several characteristics of SC in anatomy, physiology and pathophysiology have been revealed. Compare to normal, glaucomatous SC cells are more sensitive to substrate stiffness, have higher stiffness and and lower porosity leading to higher outflow resistance. And SC collapse caused by acute IOP increase is partially or totally reversal. With advanced inspection techniques, high-quality images of the SC can be obtained in vivo, which facilitates SC quantitative measurements clinically and allows us to investigate a new therapy paradigm for glaucoma. In this review, we summarize the basic and clinical research that focused on mechanisms of aqueous outflow resistance and SC changes in physiological, pathological, and post-treatment states.

    Reference
    Related
    Cited by
Get Citation

Le-Ying Wang, Guan-Yu Su, Zhen-Yu Wei,/et al.Progress in the basic and clinical research on the Schlemm’s canal. Int J Ophthalmol, 2020,13(5):816-821

Copy
Share
Article Metrics
  • Abstract:
  • PDF:
  • HTML:
  • Cited by:
Publication History
  • Received:June 20,2019
  • Revised:January 07,2020
  • Online: April 27,2020
You are the  Visitors
Governing Body：Department of Health, Provincial Government of Shaanxi, China
Organizer：Xi'an Medical Association of China
Address：Room 11707-08, Building 2, Unit 1, Wanda Plaza, No.8 Yanta North Road, Xi'an 710054, Shaanxi Province, China
Fax：(8629)82245172 Phone：(+8629)82245172/82210956
Email：ijopress@163.com
International Journal of Ophthalmology ® 2025 All Rights Reserved   The terms of CC BY-NC-ND 4.0 are applicable to all open access content.