Association of MTHFR C677T polymorphism with primary open angle glaucoma: a Meta-analysis based on 18 case-control studies
Author:
Corresponding Author:

Ping Shuai. School of Medicine, University of Electronic Science and Technology of China, Chengdu 610054, Sichuan Province, China. shuaiping@med.uestc.edu.cn; Lin Wang. Health Management Center, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu 610072, Sichuan Province, China. 764717812@qq.com

Fund Project:

Supported by National Key Research and Development Plan (No.2017YFC0113901); the Department of Science and Technology of Sichuan Province, China (No.2017JZ0039); the Science Research Project for Cadres’ Health Care of Sichuan Province (No.2017-205); Science and Technology Department of Sichuan Province (No.2019JDJQ0031; No.2020ZYD035).

  • Article
  • | |
  • Metrics
  • |
  • Reference [35]
  • |
  • Related [20]
  • | | |
  • Comments
    Abstract:

    AIM: To systematically understand the genetic association between methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and primary open angle glaucoma (POAG). METHODS: A comprehensive literature search in Google Scholar, PubMed, Science Citation Index, Foreign Medical Literature Retrieval Service, Chinese National Knowledge Infrastructure and Wanfang Databases was performed to collect all eligible studies up to August 2019. Study selection, data abstraction and study quality evaluation were performed by two independent investigators. Odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to assess the association. RESULTS: Eighteen case-control studies including 2156 cases and 2201 controls were identified. There was no significant difference in the terms of MTHFR C677T polymorphism and POAG in the Caucasian population (for T vs C OR=1.11, 95%CI: 0.88 to 1.39; for TT vs CC OR=1.01, 95%CI: 0.76 to 1.36; for TT+TC vs CC OR=1.15, 95%CI: 0.84 to 1.58 and for TT vs TC+CC OR=1.02, 95%CI: 0.78 to 1.33). However, a significant effect was revealed in the Asian population (for T vs C OR=1.34, 95%CI: 1.12 to 1.59; for TT+TC vs CC OR=1.41, 95%CI: 1.14 to 1.76). CONCLUSION: Based on 18 eligible studies, we provide a correlation between MTHFR C677T polymorphism and POAG among the Asians subgroup indicating that the T allele or TT +TC genotype may play a critical role in POAG development in Asians.

    Reference
    1 Dietze J, Blair K, Havens SJ. Glaucoma. StatPearls. Treasure Island (FL): StatPearls Publishing Copyright © 2020, StatPearls Publishing LLC; 2020.
    2 Song P, Wang J, Bucan K, Theodoratou E, Rudan I, Chan KY. National and subnational prevalence and burden of glaucoma in China: A systematic analysis. J Glob Health 2017;7(2):020705.
    3 Barbosa-Breda J, Gonçalves-Pinho M, Santos JV, Rocha-Sousa A, Abegão-Pinto L, Stalmans I, Freitas A. Trends in glaucoma surgical procedures in Portugal: a 16-year nationwide study (2000-2015). J Glaucoma 2018;27(8):682-686.
    4 Quigley HA, Broman AT. The number of people with glaucoma worldwide in 2010 and 2020. Br J Ophthalmol 2006;90(3):262-267.
    5 Tham YC, Li X, Wong TY, Quigley HA, Aung T, Cheng CY. Global prevalence of glaucoma and projections of glaucoma burden through 2040:a systematic review and Meta-analysis. Ophthalmology 2014;121(11):2081-2090.
    6 Agrawal A, Singh A, Mittal SK. Glaucoma in Asia- an epidemiological perspective. Nepal J Ophthalmol 2017;9(18):208-211.
    7 Trimmer EE. Methylenetetrahydrofolate reductase: biochemical characterization and medical significance. Curr Pharm Des 2013;19(14):2574-2593.
    8 Bagheri-Hosseinabadi Z, Imani D, Yousefi H, Abbasifard M. MTHFR gene polymorphisms and susceptibility to rheumatoid arthritis: a Meta-analysis based on 16 studies. Clin Rheumatol 2020;39(8):2267-2279.
    9 Rai V. Strong association of C677T polymorphism of methylenetetrahydrofolate reductase gene with nosyndromic cleft lip/palate (nsCL/P). Indian J Clin Biochem 2018;33(1):5-15.
    10 Liu F, Silva D, Malone MV, Seetharaman K. MTHFR A1298C and C677T polymorphisms are associated with increased risk of venous thromboembolism: a retrospective chart review study. Acta Haematol 2017;138(4):208-215.
    11 Xu F, Zhao X, Zeng SM, Li L, Zhong HB, Li M. Homocysteine, B vitamins, methylenetetrahydrofolate reductase gene, and risk of primary open-angle glaucoma: a Meta-analysis. Ophthalmology 2012;119(12):2493-2499.
    12 Moher D, Liberati A, Tetzlaff J, Altman DG; PRISMA Group. Preferred reporting items for systematic reviews and Meta-analyses: the PRISMA statement. J Clin Epidemiol 2009;62(10):1006-1012.
    13 WELLS G. The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in Meta-analyses. Symposium on Systematic Reviews: Beyond the Basics. 2000.
    14 Chiras D, Tzika K, Kokotas H, Oliveira SC, Grigoriadou M, Kastania A, Dima K, Stefaniotou M, Aspiotis M, Petersen MB, Kroupis C, Kitsos G. Development of novel LOXL1 genotyping method and evaluation of LOXL1, APOE and MTHFR polymorphisms in exfoliation syndrome/glaucoma in a Greek population. Mol Vis 2013;19:1006-1016.
    15 Fan BJ, Liu K, Wang DY, Tham CC, Tam PO, Lam DS, Pang CP. Association of polymorphisms of tumor necrosis factor and tumor protein p53 with primary open-angle glaucoma. Invest Ophthalmol Vis Sci 2010;51(8):4110-4116.
    16 Bleich S, Jünemann A, von Ahsen N, Lausen B, Ritter K, Beck G, Naumann GO, Kornhuber J. Homocysteine and risk of open-angle glaucoma. J Neural Transm (Vienna) 2002;109(12):1499-1504.
    17 Dixit A, Prakash D, Kumar S, Mutsuddi M, Maurya O, Singh SP, Chandra A. Genetic analysis of patients with primary Open Angle Glaucoma (POAG) in north Indian population. The J of Community Health Management 2015;02(4);168-178.
    18 Al-Shahrani H, Al-Dabbagh N, Al-Dohayan N, Arfin M, Al-Asmari M, Rizvi S, Al-Asmari A. Association of the methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism with primary glaucoma in Saudi population. BMC Ophthalmol 2016;16(1):156.
    19 Sekeroglu MA, Irkec M, Mocan MC, Orhan M. Hereditary thrombophilic factors in glaucoma. J Glaucoma 2016;25(2):203-207.
    20 Fingert JH, Kwon YH, Moore PA, Johnston RM, Kim KY, Sheffield VC, Alward WLM, Stone EM. The C677T variant in the methylenetetrahydrofolate reductase gene is not associated with disease in cohorts of pseudoexfoliation glaucoma and primary open-angle glaucoma patients from Iowa. Ophthalmic Genet 2006;27(2):39-41.
    21 Michael S, Qamar R, Akhtar F, Khan WA, Ahmed A. C677T polymorphism in the methylenetetrahydrofolate reductase gene is associated with primary closed angle glaucoma. Mol Vis 2008;14:661-665.
    22 Zetterberg M, Tasa G, Palmér MS, Juronen E, Toover E, Blennow K, Zetterberg H. Methylenetetrahydrofolate reductase genetic polymorphisms in patients with primary open-angle glaucoma. Ophthalmic Genet 2007;28(2):47-50.
    23 Mossbock G, Weger M, Faschinger C, Steinbrugger I, Temmel W, Schmut O, Renner W, Hufnagel C, Stanger O. Methylenetetrahydrofolatereductase (MTHFR) 677C>T polymorphism and open angle glaucoma. Mol Vis 2006;12:356-359.
    24 Mabuchi F, Tang S, Kashiwagi K, Yamagata Z, Iijima H, Tsukahara S. Methylenetetrahydrofolate reductase gene polymorphisms c.677C/T and c.1298A/C are not associated with open angle glaucoma. Mol Vis 2006;12:735-739.
    25 Zacharaki F, Hadjigeorgiou GM, Koliakos GG, Morrison MA, Tsezou A, Chatzoulis DZ, Almpanidou P, Topouridou K, Karabatsas CH, Pefkianaki M, DeAngelis MM, Tsironi EE. Plasma homocysteine and genetic variants of homocysteine Metabolism enzymes in patients from central Greece with primary open-angle glaucoma and pseudoexfoliation glaucoma. Clin Ophthalmol 2014;8:1819-1825.
    26 Buentello-Volante B, Elizondo-Olascoaga C, Miranda-Duarte A, Guadarrama-Vallejo D, Cabral-Macias J, Zenteno JC. Association study of multiple gene polymorphisms with the risk of adult-onset primary open-angle glaucoma in a Mexican population. Exp Eye Res 2013;107:59-64.
    27 Clement CI, Goldberg I, Healey PR, Graham SL. Plasma homocysteine, MTHFR gene mutation, and open-angle glaucoma. J Glaucoma 2009;18(1):73-78.
    28 Micheal S, Qamar R, Akhtar F, Khan MI, Khan WA, Ahmed A. MTHFR gene C677T and A1298C polymorphisms and homocysteine levels in primary open angle and primary closed angle glaucoma. Mol Vis 2009;15:2268-2278.
    29 Jünemann AG, von Ahsen N, Reulbach U, Roedl J, Bönsch D, Kornhuber J, Kruse FE, Bleich S. C677T variant in the methylentetrahydrofolate reductase gene is a genetic risk factor for primary open-angle glaucoma. Am J Ophthalmol 2005;139(4):721-723.
    30 Nilforoushan N, Aghapour S, Raoofian R, Saee Rad S, Greene WK, Fakhraie G, Heidari M. Lack of association between the C677T single nucleotide polymorphism of the MTHFR gene and glaucoma in Iranian patients. Acta Med Iran 2012;50(3):208-212.
    31 Gupta S, Bhaskar PK, Bhardwaj R, Chandra A, Chaudhry VN, Chaudhry P, Ali A, Mukherjee A, Mutsuddi M. MTHFR C677T predisposes to POAG but not to PACG in a North Indian population: a case control study. PLoS One 2014;9(7):e103063.
    32 Huo Y, Zou H, Lang M, Ji SX, Yin XL, Zheng Z, Liu W, Chen CL, Yuan RD, Ye J. Association between MTHFR C677T polymorphism and primary open-angle glaucoma: a Meta-analysis. Gene 2013;512(2): 179-184.
    33 Gohari M, Mirjalili SA, Akbarian-Bafghi MJ, Jarahzadeh MH, Zare-Shehneh M, Neamatzadeh H. Association of MTHFR C677T and A1298C polymorphisms with glaucoma risk: a systematic review Meta-analysis based 42 case-control studies. Rom J Ophthalmol 2019;63(2):107-118.
    34 Zhang L, Chen B. Correlation between MTHFR polymorphisms and glaucoma: A Meta-analysis. Mol Genet Genomic Med 2019;7(4):e00538.
    35 Woo SJ, Kim JY, Kim DM, Park SS, Ko HS, Yoo T. Investigation of the association between 677C>T and 1298A>C 5,10-methylenetetra- hydrofolate reductase gene polymorphisms and normal-tension glaucoma. Eye (Lond) 2009;23(1):17-24.
    Cited by
    Comments
    Comments
    分享到微博
    Submit
Get Citation

Yu-Mei Yang, Yu-Ping Liu, Dong-Yu Li,/et al.Association of MTHFR C677T polymorphism with primary open angle glaucoma: a Meta-analysis based on 18 case-control studies. Int J Ophthalmol, 2021,14(6):896-902

Copy
Share
Article Metrics
  • Abstract:751
  • PDF: 763
  • HTML: 0
  • Cited by: 0
Publication History
  • Received:April 10,2020
  • Revised:July 27,2020
  • Online: April 23,2021