Home > Archive>Volume 15, Issue 1, 2022 >106-112. DOI:10.18240/ijo.2022.01.16
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Foveal structure changes in infants treated with anti-VEGF therapy or laser therapy guided by optical coherence tomography angiography for retinopathy of prematurity
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Jian-Hong Liang. Department of Ophthalmology & Clinical Centre of Optometry, Peking University People’s Hospital, 11 Xizhimen South Street, Xicheng District, Beijing 100044, China. drliangjianhong@126.com

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    Abstract:

    AIM: To evaluate foveal vessel density (VD) and foveal thickness using optical coherence tomography angiography (OCTA) in retinopathy of prematurity (ROP) children treated with laser photocoagulation or anti-vascular endothelial growth factor (VEGF) injection. Additionally, we assessed the relationship between foveal microvascular anomalies and different therapies in ROP children. METHODS: This was a single-center, retrospective study of patients with a diagnosis of type 1 ROP. Twenty-three eyes (14 patients) treated with anti-VEGF injection and twenty-nine eyes (17 patients) treated with laser coagulation were included in this study. The foveal VD, inner thickness and full thickness were measured at the central 0°, 2° to 8°, and 8° of the retina (centered on the fovea) using OCTA and cross-sectional OCT, respectively. RESULTS: Foveal VD, inner thickness and full thickness were significantly smaller within the central 8° of the retina in ROP children treated with anti-VEGF injection than in those treated with laser photocoagulation (P=0.013, 0.009, 0.036, respectively). The full thickness was also smaller in the anti-VEGF group than in the laser group at the central 0° of the retina (P=0.010). The grade of foveal hypoplasia is lower in the anti-VEGF group than in the laser group (P=0.045). Multivariable analysis did not find any risk factors associated with visual acuity in our study. CONCLUSION: In children with type 1 ROP, the better structural development of fovea in those who were treated with anti-VEGF injection compared with laser photocoagulation are identified. However, visual acuity outcomes are similar 70mo after the treatments.

    Reference
    1 Ni YQ, Huang X, Xue K, Yu J, Ruan L, Shan HD, Xu GZ. Natural involution of acute retinopathy of prematurity not requiring treatment: factors associated with the time course of involution. Invest Ophthalmol Vis Sci 2014;55(5):3165-3170.
    2 Lee AC, Katz J, Blencowe H, et al. National and regional estimates of term and preterm babies born small for gestational age in 138 low-income and middle-income countries in 2010. Lancet Glob Health 2013;1(1):e26-e36.
    3 Wu T, Zhang L, Tong Y, Qu Y, Xia B, Mu DZ. Retinopathy of prematurity among very low-birth-weight infants in China: incidence and perinatal risk factors. Invest Ophthalmol Vis Sci 2018;59(2):757-763.
    4 Shah VA, Yeo CL, Ling YL, Ho LY. Incidence, risk factors of retinopathy of prematurity among very low birth weight infants in Singapore. Ann Acad Med Singap 2005;34(2):169-178.
    5 Dogra MR, Katoch D, Dogra M. An update on retinopathy of prematurity (ROP). Indian J Pediatr 2017;84(12):930-936.
    6 Nonobe N, Kaneko H, Ito Y, et al. Optical coherence tomography angiography of the foveal avascular zone in children with a history of treatment-requiring retinopathy of prematurity. Retina 2019;39(1):111-117.
    7 Takagi M, Maruko I, Yamaguchi A, Kakehashi M, Hasegawa T, Iida T. Foveal abnormalities determined by optical coherence tomography angiography in children with history of retinopathy of prematurity. Eye (Lond) 2019;33(12):1890-1896.
    8 Chen YC, Chen YT, Chen SN. Foveal microvascular anomalies on optical coherence tomography angiography and the correlation with foveal thickness and visual acuity in retinopathy of prematurity. Graefes Arch Clin Exp Ophthalmol 2019;257(1):23-30.
    9 Bashinsky AL. Retinopathy of Prematurity. N C Med J 2017;78(2):124-128.
    10 Wu AL, Wu WC. Anti-VEGF for ROP and pediatric retinal diseases. Asia Pac J Ophthalmol (Phila) 2018;7(3):145-151.
    11 Pertl L, Steinwender G, Mayer C, Hausberger S, Pöschl EM, Wackernagel W, Wedrich A, El-Shabrawi Y, Haas A. A systematic review and meta-analysis on the safety of vascular endothelial growth factor (VEGF) inhibitors for the treatment of retinopathy of prematurity. PLoS One 2015;10(6):e0129383.
    12 Morin J, Luu TM, Superstein R, Ospina LH, Lefebvre F, Simard MN, Shah V, Shah PS, Kelly EN. Neurodevelopmental outcomes following bevacizumab injections for retinopathy of prematurity. Pediatrics 2016;137(4):e20153218.
    13 Chen YC, Chen SN. Foveal microvasculature, refractive errors, optical biometry and their correlations in school-aged children with retinopathy of prematurity after intravitreal antivascular endothelial growth factors or laser photocoagulation. Br J Ophthalmol 2020;104(5):691-696.
    14 Patz A. The new international classification of retinopathy of prematurity. Arch Ophthalmol 1984;102(8):1129.
    15 Early Treatment for Retinopathy of Prematurity Cooperative Group, Good WV, Hardy RJ, Dobson V, Palmer EA, Phelps DL, Tung B, Redford M. Final visual acuity results in the early treatment for retinopathy of prematurity study. Arch Ophthalmol 2010;128(6):663-671.
    16 Thomas MG, Kumar A, Mohammad S, Proudlock FA, Engle EC, Andrews C, Chan WM, Thomas S, Gottlob I. Structural grading of foveal hypoplasia using spectral-domain optical coherence tomography a predictor of visual acuity? Ophthalmology 2011;118(8):1653-1660.
    17 Pedersen HR, Hagen LA, Landsend ECS, Gilson SJ, Utheim ØA, Utheim TP, Neitz M, Baraas RC. Color Vision in Aniridia. Invest Ophthalmol Vis Sci 2018;59(5):2142-2152.
    18 Campbell JP, Nudleman E, Yang JL, Tan O, Chan RVP, Chiang MF, Huang D, Liu GJ. Handheld optical coherence tomography angiography and ultra-wide-field optical coherence tomography in retinopathy of prematurity. JAMA Ophthalmol 2017;135(9):977-981.
    19 Vinekar A, Chidambara L, Jayadev C, Sivakumar M, Webers CA, Shetty B. Monitoring neovascularization in aggressive posterior retinopathy of prematurity using optical coherence tomography angiography. J AAPOS 2016;20(3):271-274.
    20 Falavarjani KG, Iafe NA, Velez FG, Schwartz SD, Sadda SR, Sarraf D, Tsui I. Optical coherence tomography angiography of the fovea in children born preterm. Retina 2017;37(12):2289-2294.
    21 Cuenca N, Ortuño-Lizarán I, Sánchez-Sáez X, Kutsyr O, Albertos-Arranz H, Fernández-Sánchez L, Martínez-Gil N, Noailles A, López-Garrido JA, López-Gálvez M, Lax P, Maneu V, Pinilla I. Interpretation of OCT and OCTA images from a histological approach: clinical and experimental implications. Prog Retin Eye Res 2020;77:100828.
    22 Provis JM, Hendrickson AE. The foveal avascular region of developing human retina. Arch Ophthalmol 2008;126(4):507-511.
    23 Springer AD, Hendrickson AE. Development of the primate area of high acuity. 1. Use of finite element analysis models to identify mechanical variables affecting pit formation. Vis Neurosci 2004;21(1):53-62.
    24 Yanni SE, Wang JY, Chan M, Carroll J, Farsiu S, Leffler JN, Spencer R, Birch EE. Foveal avascular zone and foveal pit formation after preterm birth. Br J Ophthalmol 2012;96(7):961-966.
    25 Dubis AM, Costakos DM, Subramaniam CD, Godara P, Wirostko WJ, Carroll J, Provis JM. Evaluation of normal human foveal development using optical coherence tomography and histologic examination. Arch Ophthalmol 2012;130(10):1291-1300.
    26 Hendrickson A, Possin D, Vajzovic L, Toth CA. Histologic development of the human fovea from midgestation to maturity. Am J Ophthalmol 2012;154(5):767-778.e2.
    27 Vogel RN, Strampe M, Fagbemi OE, Visotcky A, Tarima S, Carroll J, Costakos DM. Foveal development in infants treated with bevacizumab or laser photocoagulation for retinopathy of prematurity. Ophthalmology 2018;125(3):444-452.
    28 Hammer DX, Iftimia NV, Ferguson RD, Bigelow CE, Ustun TE, Barnaby AM, Fulton AB. Foveal fine structure in retinopathy of prematurity: an adaptive optics Fourier domain optical coherence tomography study. Invest Ophthalmol Vis Sci 2008;49(5):2061-2070.
    29 McAllister JT, Dubis AM, Tait DM, Ostler S, Rha J, Stepien KE, Summers CG, Carroll J. Arrested development: high-resolution imaging of foveal morphology in albinism. Vision Res 2010;50(8): 810-817.
    30 Rosén R, Sjöstrand J, Nilsson M, Hellgren K. A methodological approach for evaluation of foveal immaturity after extremely preterm birth. Ophthalmic Physiol Opt 2015;35(4):433-441.
    31 Ludwig CA, Chen TA, Hernandez-Boussard T, Moshfeghi AA, Moshfeghi DM. The epidemiology of retinopathy of prematurity in the United States. Ophthalmic Surg Lasers Imaging Retina 2017;48(7):553-562.
    32 Vander JF, McNamara JA, Tasman W, Brown GC. Revised indications for early treatment of retinopathy of prematurity. Arch Ophthalmol 2005;123(3):406-407; discussion 409-410.
    33 Sankar MJ, Sankar J, Mehta M, Bhat V, Srinivasan R. Anti-vascular endothelial growth factor (VEGF) drugs for treatment of retinopathy of prematurity. Cochrane Database Syst Rev 2016;2:CD009734.
    34 Wu WC, Lin RI, Shih CP, Wang NK, Chen YP, Chao AN, Chen KJ, Chen TL, Hwang YS, Lai CC, Huang CY, Tsai S. Visual acuity, optical components, and macular abnormalities in patients with a history of retinopathy of prematurity. Ophthalmology 2012;119(9):1907-1916.
    35 Erol MK, Coban DT, Özdemir Ö, Tunay ZÖ, Bilgin AB, Dogan B. Spectral-domain OCT Analyses of macular changes after ranibizumab therapy for type 1 retinopathy of prematurity. J Pediatr Ophthalmol Strabismus 2015;52(3):152-158.
    36 Lepore D, Quinn GE, Molle F, Baldascino A, Orazi L, Sammartino M, Purcaro V, Giannantonio C, Papacci P, Romagnoli C. Intravitreal bevacizumab versus laser treatment in type 1 retinopathy of prematurity: report on fluorescein angiographic findings. Ophthalmology 2014;121(11):2212-2219.
    37 Lepore D, Quinn GE, Molle F, Orazi L, Baldascino A, Ji MH, Sammartino M, Sbaraglia F, Ricci D, Mercuri E. Follow-up to age 4y of treatment of type 1 retinopathy of prematurity intravitreal bevacizumab injection versus laser: fluorescein angiographic findings. Ophthalmology 2018;125(2):218-226.
    38 Provis JM, Dubis AM, Maddess T, Carroll J. Adaptation of the central retina for high acuity vision: cones, the fovea and the avascular zone. Prog Retin Eye Res 2013;35:63-81.
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Xun Deng, Yong Cheng, Xue-Mei Zhu,/et al.Foveal structure changes in infants treated with anti-VEGF therapy or laser therapy guided by optical coherence tomography angiography for retinopathy of prematurity. Int J Ophthalmol, 2022,15(1):106-112

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Publication History
  • Received:December 11,2020
  • Revised:April 26,2021
  • Online: December 24,2021
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