Role of 7-methylxanthine in myopia prevention and control: a mini-review
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Dong-Mei Cui. Shenzhen Eye Hospital, Jinan University, Shenzhen Eye Institute, 18 Zetian Road, Futian District, Shenzhen 518040, Guangdong Province, China.


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Supported by Shenzhen Special Fund for Sustainable Development Science and Technology (No.2022N068); Sanming Project of Medicine in Shenzhen (No.SZSM202011015).

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    Myopia is becoming increasingly common. By 2050 around 10% of the world’s population is expected to be highly myopic (<-5 diopters) and therefore particularly at risk of suffering from sight-threatening complications. Currently used myopia control treatments, such as multifocal soft contact lenses or spectacle lenses, orthokeratology, and atropine eyedrops, either do not completely arrest myopia progression or are associated with significant ocular and possibly systemic side effects. A new candidate for pharmaceutical control of myopia progression and excessive eye elongation, the non-selective adenosine antagonist 7-methylxanthine (7-MX), appears to be non-toxic and effective in reducing myopia progression and axial eye growth in experimental and clinical studies. The latest findings regarding 7-MX for myopia control and evaluate its potential as a supplement to existing treatment options were reviewed.

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Lu Lai, Klaus Trier, Dong-Mei Cui. Role of 7-methylxanthine in myopia prevention and control: a mini-review. Int J Ophthalmol, 2023,16(6):969-976

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  • Received:January 31,2023
  • Revised:April 12,2023
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  • Online: May 30,2023
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