Zhen-Zhen Liu and Guang-Ming Jin. State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, 7# Jinsui Road, Guangzhou 510000, Guangdong Province, China. firstname.lastname@example.org; email@example.com
Supported by the National Natural Science Foundation of China (No.81900841); the Science and Technology Program of Guangzhou, China (No.202201011815); the Guangdong Basic and Applied Basic Research Foundation (No.2022A1515011181); the Teaching Reform Research Program of Sun Yat-sen University (No.JX3030604024); the Youth Project of State Key Laboratory of Ophthalmology (No.2021QN02); the Construction Project of High-Level Hospitals in Guangdong Province (No.303020102).
AIM: To explore the hotspots and frontiers of genetic research on pediatric cataracts. METHODS: Global publications from 2013 to 2022 related to genes in pediatric cataracts were extracted from the Web of Science Core Collection, and were analyzed in terms of the publication counts, countries, journals, authors, keywords, cited references, subject categories, and the underlying hotspots and frontiers. RESULTS: Totally 699 publications were included in the final analysis. The predominant actors were identified, with China (n=240) and PLoS One (n=33) being the most productive country and journal respectively. The research hotspots extracted from keywords were crystallin gene mutations, pathogenicity evaluation, phenotypes of ocular and neurodevelopmental abnormalities, genes encoding membrane proteins, and diagnosis of multisystemic disorders. The co-cited articles formed 10 clusters of research topics, including FYCO1 (56 items), mutation screening (43 items), gap junction (29 items), the Warburg Micro syndrome (29 items), ephrin-A5 (28 items), novel mutation (24 items), eye development and function (22 items), cholestanol (7 items), OCRL (6 items), and pathogenicity prediction (3 items). The research frontiers were FYCO1, ephrin-A5, and cholestanol. Cell biology showed the strongest bridging effects among different disciplines in the field (betweenness centrality=0.44). CONCLUSION: With the progress in next-generation sequencing and multidisciplinary collaboration, genetic research on pediatric cataracts broadens the knowledge scope of the crystalline lens, as well as other organs and systems, shedding light on the molecular mechanisms of systemic diseases. Cell biology may integrate multidisciplinary content to address cutting-edge issues in the field.
Yuan Tan, Wei Jiang, Le-Yi Hu, et al. Hotspots and frontiers of genetic research on pediatric cataracts from 2013 to 2022: a scientometric analysis. Int J Ophthalmol 2023;16(10):1682-1691Copy