Home > Archive>Volume 18, Issue 3, 2025 >469-477. DOI:10.18240/ijo.2025.03.14
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Central alterations of brain networks in patients with optic neuritis: a resting state fMRI study
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Corresponding Author:

Yi Shao. Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, National Clinical Research Center for Eye Diseases, Shanghai 200080, China. freebee99@163.com; Qiong Zhou. Department of Ophthalmology, the First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang 330006, Jiangxi Province, China. qiongz-ms@126.com

Fund Project:

Supported by National Natural Science Foundation of China (No.82160195; No.82460203); Key R & D Program of Jiangxi Province (No.20223BBH80014).

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    Abstract:

    AIM: To assess the alterations in the resting-state function connections between the two cerebral hemispheres in patients with optic neuritis (ON) and healthy controls (HCs). METHODS: A total of 12 ON patients (six males and six females) and 12 HCs (six males and six females) who were highly matched for sex, age, and educational level were recruited. They underwent functional magnetic resonance imaging (fMRI), testing and brain activities were assessed using the degree centrality (DC) method. Correlation analysis between the mean DC values in specific brain areas and behavior performances was analyzed as well. Linear correlations between A anxiety scale (AS) and depression scale (DS) values and DC values in brain regions of patients with ON were also analyzed. RESULTS: The areas that showed a higher DC value in ON patients were the right angular gyrus and bilateral precuneus, while the left insula and left superior temporal gyrus (LSTG) were regions that presented a lower DC value in ON patients. A receiver operating characteristic (ROC) curve analysis confirmed the accuracy of the area under the curve (AUC) assessment. Linear analysis showed anxiety scale (AS) and depression scale (DS) values in the left insula were both negatively correlated with DC values, while best corrected visual acuity logMAR-R (BCVA logMAR-R) showed a negative correlation with DC in the LSTG. CONCLUSION: The study explores altered brain activities of specific regions in patients with ON. The results provide clues for revealing the underlying mechanism of ON development.

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Liang Huang, Dan Song, Lei Zhong,/et al.Central alterations of brain networks in patients with optic neuritis: a resting state fMRI study. Int J Ophthalmol, 2025,18(3):469-477

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Publication History
  • Received:August 12,2024
  • Revised:October 14,2024
  • Online: February 20,2025
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