As a non-invasive surgical procedure ultrasound cyclo-plasty (UCP) has gained attention among ophthalmologists in recent years. Derived from the application of high-intensity focused ultrasound, it has been utilized for the treatment of various types of glaucoma, demonstrating notable efficacy and safety. This review focuses on the efficacy and safety of UCP in treating glaucoma among Asian populations. By summarizing and analyzing existing literature on indications, therapeutic outcomes, and safety profiles, this review further highlights the unique advantages of UCP in glaucoma treatment compared to traditional surgical approaches. These advantages include broader indications, non-invasive nature, quantifiable treatment, excellent intraocular pressure-lowering effects, fewer adverse reactions, and high safety. Additionally, by introducing the underlying mechanism of action, this review explores the factors influencing its therapeutic efficacy, providing theoretical insights for clinical practice and demonstrating UCP’s potential in glaucoma management.