Inhibitory effects of pioglitazone on alkaline burninduced corneal neovascularization in rats
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    Abstract:

    AIM: To investigate the effects of pioglitazone on corneal neovascularization(CNV)induced by alkaline burn in rats and on expression of vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (b-FGF). ·METHODS: CNV was induced by alkaline burn in rats which were then administered pioglitazone subconjunctivally. Corneal angiogenesis was evaluated and observed with a slit lamp microscope and the VEGF and b-FGF level were determined by immunohistochemistry and Western blot at different intervals. ·RESULTS: The CNV of the rats was shown two days after alkaline burn, and reached its highest level in 7-10 days. The mean values of the area and length of neovascularization and the VEGF and b-FGF levels in the pioglitazone-treated group were significantly lower than those in the control group at various time. · CONCLUSION: Local application of pioglitazone could remarkably inhibit CNV, probably by means of downregulation of VEGF and b-FGF expression.

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Yi-Xia Zhang, Ming-Chang Zhang. Inhibitory effects of pioglitazone on alkaline burninduced corneal neovascularization in rats. Int J Ophthalmol, 2008,1(2):99-103

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Publication History
  • Received:April 09,2008
  • Revised:May 14,2008
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