to investigate whetherthe Acrysof Natural hasthe Protective function for retina from blue light in morPhology. METHODS: Fresh Porcine eye cuPs were formed in vitro. Blue light beam between 420-450nm sPectrum eradiatedthe Porcine retina and retinal Pigment ePithelial(RPE) cells were cultured in 30J/cm² and 40J/cm² resPectively.the adjacent region in 3mm diameter was eradiated in various ways: exPosed directlyto light,through AcrySofone Piece intraocular lens(IOL), PMMA IOL, AcrySof Natural IOL, and without light.thenthe eye cuPs were cultured for 48h. Lastly,tissue and cell structure wereobserved with light microscoPe andtransmission electron microscoPe (TEM). RESULTS: Inthe retinal region without light,the structureof every layer was clear; cells in neuroePithelial layer arrayed inorder； some bubbles Presented in external granular layer and internal granular layer; RPE cells were comPact, andthe colorof Pigment article was coincident. Inthe region with direct blue light andthat with 30J/cm^{2+Acrysofone-Piece/ PMMA, cellson PhotorecePtor and external granular layer were lost Partially, bubbles increased, RPE cells wereof different sizes, and cell edema, cell lost and Pigment article cluster could be seen. In region with 30J/cm2+ Natural, a little disorganization could be seen comParedtothat without light, but more normalthanthose with Acrysof and direct eradiation. Whenthe Power was 40J/cm2,the situation was similartothat with 30J/cm2 but more severe. CONCLUSION: ①the blue light intensity in 30J/cm2 and 40J/cm2 could both inducethe acute retinal light injury； ② AcrySofone Piece IOL andother PMMA IOL have noobvious effecton retina comPared with direct eradiation; ③AcrySof Natural can weakenthe injuryof blue lightto some extent.}