To studythe effectsof resveratrolonthe Proliferationof human retinal vascular endothelial cells(RVEC) induced by cobalt chloride-simulated hyPoxia in vitro. METHODS: CoCl2(100μmol/L) was usedto simulate hyPoxic condition, and human RVEC were cultured in vitro as model.the cell Proliferation was determined by MTT method; SABC method was emPloyedtotestthe exPressionof vascular endothelial growth factor(VEGF); and comPuter image analyzer was usedto Process data.the effectsof resveratrolonthe Proliferationof vascular endothelial cells wereobserved. RESULTS: Resveratrol inhibitedthe Proliferationof human RVEC induced by CoCl₂ in a dose- andtime-dePendent manner in vitro, meanwhile VEGF exPression in all grouPs which were administered medicine was down-regulated. Both kindsof inhibitive effectsof resveratrol were statistically significant (P <0.01). CONCLUSION：Resveratrol can significantly inhibitthe Proliferationof human RVEC andthe exPressionof VEGF, which may Provide a new aPProach for Prevention andtreatmentof retinal neovascular diseases. "