Inhibitory effect of tetrandrine eye drops on corneal allograft rejection in rats
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Inhibitory effect of tetrandrine eye drops on corneal allograft rejection in rats. Int J Ophthalmol

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    Abstract:

    To observe the effect of tetrandrine (Tet) eye drops of different concentrations on corneal graft and on allograft rejection in rats. · METHODS: Models of allograft rejection were set up in 64 SD rats and they were then randomly divided into 3, 5, 10g/L tetrandrine eye drops-treated and control groups. At different times postoperatively, neovascularization and inflammation of corneal graft were observed using slit-lamp microscopy, HE staining, light microscopy and microphoto-analysis. · RESULTS: The graft was infiltrated mainly with lymphocytes and mononuclear-macrophages. Corneal neovascularization and inflammation were significantly inhibited in the 5g/L Tet-treated group (P <0.05), compared with control group on day 7, 14, 21, 28 postoperatively. · CONCLUSION: Corneal edema and corneal epithelial bubble appear when the graft is treated with tetrandrine of higher concentration (10g/L), but 5g/L Tet eye drops significantly inhibit corneal allograft rejection in rats without serious side-effects.

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Yue Zhang, Shi Zhang, Xiao-Ping Chen, et al. Inhibitory effect of tetrandrine eye drops on corneal allograft rejection in rats. Int J Ophthalmol, 2008,1(4):336-338

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Publication History
  • Received:April 02,2008
  • Revised:October 18,2008
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