The role of MMP-9 and TIMP-3 in induction of choroidal neovascularization in a murine model
DOI:
Author:
Corresponding Author:

Affiliation:

Clc Number:

Fund Project:

National Natural Science Foundation of China (No.60378040) and Foundation of Scientific and Technical Committee of Shanghai (No.024119055)

  • Article
  • |
  • Figures
  • |
  • Metrics
  • |
  • Reference
  • |
  • Related
  • |
  • Cited by
  • |
  • Materials
  • |
  • Comments
    Abstract:

    AIM: To examine the expression of MMP-9 and TIMP-3 mRNA during choroidal neovascularization (CNV) in a murine model and to investigate the role of them in the development of CNV. METHODS: CNV was induced in C57BL/6J mice by intensive diode laser (810nm) photocoagulation (120mW, 75μm, 0.1s) of the fundus whereafter eyes were enucleated at 1, 3days, 1, 2, and 4 weeks. The MMP-9 and TIMP-3 mRNA expressions were analyzed using in situ hybridization and image analysis system. RESULTS: Both expression of MMP-9 and TIMP-3 mRNA had dynamic changes. For MMP-9, the expression was 1, 2, 4 wk>3d>1d (P <0.05), whereas TIMP-3 mRNA, 3d, 1, 2, 4 wk>1d (P <0.05). CONCLUSION: The imbalance between the changes of MMP-9 and TIMP-3 may accelerate the degrading of extracelluar matrix, and then be involved in the pathogenesis of CNV.

    Reference
    Related
    Cited by
Get Citation

Shi-Sheng Zhang, , ,et al. The role of MMP-9 and TIMP-3 in induction of choroidal neovascularization in a murine model. Int J Ophthalmol, 2009,2(2):118-122

Copy
Share
Article Metrics
  • Abstract:
  • PDF:
  • HTML:
  • Cited by:
Publication History
  • Received:January 21,2009
  • Revised:April 29,2009
  • Adopted:
  • Online:
  • Published: