Expression of transforming growth factor-β type I receptor and transforming growth factor-β type II receptor in rat retina
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National Natural Science Foundation of China (No. 30271391); Foundation of Scientific Research Program of Health Bureau of Shanghai City, China(No. 034124); Foundation of Training Plan for a Hundred Transcentury Excellent Subject Leaders in Shanghai Public Health System, China (No. 057)

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    Abstract:

    AIM: To quantitatively investigate the gene expression of transforming growth factor-β type I receptor (TβR I) and trans- forming growth factor-β type II receptor (TβR II) in rat retina. METHODS: Sprague-Dawley rats were chosen in this research. Gene expression was detected quantitatively by reverse transcription polymerase chain reaction (RT-PCR) analysis. RESULTS: The expression level of TβR I and TβR II were 0.00034±0.00013 and 0.0001±0.00005, respectively. The expression level of TβR I was obviously higher than that of TβR II in the rat retina with statistical significance (P <0.01). The ratio of TβR I /TβR II was 3.9±1.7. CONCLUSION: Real time quantitative RT-PCR is an effective method to detect differential expression genes in retina. The expression change of TβR I and TβR II may play an important role in the pathogenesis of retinopathy, which need further investigation on its significance in the development of proliferation retinopathy.

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Wei Shen, Lin Liu. Expression of transforming growth factor-β type I receptor and transforming growth factor-β type II receptor in rat retina. Int J Ophthalmol, 2009,2(3):204-206

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Publication History
  • Received:May 02,2009
  • Revised:August 12,2008
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