Increased expression of Ets-1 in the diabetic retina of streptozotocin-induced rat model
DOI:
Author:
Corresponding Author:

Affiliation:

Clc Number:

Fund Project:

  • Article
  • |
  • Figures
  • |
  • Metrics
  • |
  • Reference
  • |
  • Related
  • |
  • Cited by
  • |
  • Materials
  • |
  • Comments
    Abstract:

    AIM: To determine the involvement of Ets-1 in the pathological progress of the experimental diabetic retina. METHODS: Diabetes was induced by intraperitoneal injection of STZ. Total RNA and total proteins were isolated from retinas of experimental and control eyes at 4 weeks after STZ-injection and were assessed by Northern blot analysis and Western blot analysis, respectively. RESULTS: Expression of both Ets-1 mRNA and Ets-1 protein was significantly increased in the experimental diabetic rat's retina after STZ-injection compared with the control group (P <0.001). CONCLUSION: Our results indicate that Ets-1 is involved in the pathological progress of experimental diabetic retina. Further studies should be conducted to focus on the relationship between Ets-1 and VEGF in the diabetic retina.

    Reference
    Related
    Cited by
Get Citation

Zhao-Jiang Du, Peng Li, Yan-Nian Hui, et al. Increased expression of Ets-1 in the diabetic retina of streptozotocin-induced rat model. Int J Ophthalmol, 2009,2(3):231-234

Copy
Share
Article Metrics
  • Abstract:
  • PDF:
  • HTML:
  • Cited by:
Publication History
  • Received:May 27,2009
  • Revised:August 02,2009
  • Adopted:
  • Online:
  • Published: